VWF/ADAMTS13 ratio as a potential biomarker for early detection of hepatocellular carcinoma

BMC Gastroenterology

Table 3 The receiver operating characteristic (ROC) curve of the biomarkers

Variable	Sensitivity	Specificity	AUC
AFP	0.68	0.55	0.61
DCP	0.46	0.85	0.58
AFP-L3%	0.54	0.93	0.74
VEGF	0.47	1.00	0.67
VEGFR2	0.59	0.58	0.59
ADAMTS13:AC	0.56	0.79	0.67
VWF:Ag	0.59	0.75	0.63
VWF:Ag/ADAMTS13:AC	0.51	0.95	0.73

AFP alpha fetoprotein, DCP des-γ-carboxy prothrombin
AFP-L3%, Lens culinaris agglutinin-reactive alpha-fetoprotein
VEGF vascular endothelial growth factor, VEGFR-2 VEGF receptor-2
ADAMTS13 a disintegrin-like and metalloproteinase with thrombospondin type 1 motifs 13
VWF, von Willebrand factor; ADAMTS13:AC, ADAMTS13 activity
VWF:Ag, von Willebrand factor antigen; VWF:Ag/ADAMTS13:AC, ratio of VWF:Ag to ADAMTS13:AC
AUC, area under the curve

ISSN: 1471-230X