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Table 2 Subgroup analysis primary vs. secondary liver failure & ELS – Parameters & definitions

From: Extracorporeal liver support: trending epidemiology and mortality - a nationwide database analysis 2007–2015

“Primary liver failure group”

 Alcoholic liver disease

ICD K70

 Liver failure, not elsewhere classified (includes fulminant liver failure)

ICD K72

 Fibrosis and cirrhosis of the liver

ICD K74

 Other diseases of the liver

ICD K76

 Other diseases of the biliary tract

ICD K83

 Malignant neoplasm of liver and intrahepatic bile ducts

ICD C22

 Congenital malformations of the gallbladder, bile ducts and liver

ICD Q44

 Disorders of mineral metabolism (includes M. Wilson, Hemochromatosis)

ICD E83

 Other metabolic disorders

ICD E88

 Other venous embolism and thrombosis (including Budd-Chiari-Syndrome)

ICD I82

“Secondary liver failure group” – Cardiac surgery patient population

 Operative external circulation (when using the heart-lung machine)

OPS 8–851

 Operations on valves and septa of the heart and cardiac vessel

OPS 5–35

 Surgery on the coronary vessels

OPS 5–36

 Rhythm surgery and other operations on the heart and pericardium

OPS 5–37

 Resection and replacement (interposition) at the aorta

OPS 5–384

  1. Primary liver failure group coding was chosen according to typical criteria by EuroTransplant for performed non-high-urgency liver transplantation (See reference [12], Jochman et al.). Secondary liver failure group (“Cardiac population”) was chosen according to predefined cardiac surgical procedures (coronary, valvular and aortic surgery performed in combination with heart-lung machine)