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Table 3 The 20 most influential articles in the microbiome-gut-brain axis research

From: Global research trends in microbiome-gut-brain axis during 2009–2018: a bibliometric and visualized study

SCRa Authors Title Year of publication Source title Cited by
1st Nicholson et al. [56] “Host-gut microbiota metabolic interactions” 2012 Science 1490
2nd Cryan and Dinan [57] “Mind-altering microorganisms: The impact of the gut microbiota on brain and behavior” 2012 Nature Reviews Neuroscience 1204
3rd Heijtz et al. [58] “Normal gut microbiota modulates brain development and behavior” 2011 Proceedings of the National Academy of Sciences of the United States of America 1116
4th Hsiao et al. [59] “Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders” 2013 Cell 1041
5th Bravo et al. [60] “Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve” 2011 Proceedings of the National Academy of Sciences of the United States of America 1028
6th Foster and McVey Neufeld [61] “Gut-brain axis: How the microbiome influences anxiety and depression” 2013 Trends in Neurosciences 612
7th Bercik et al. [62] “The intestinal microbiota affect central levels of brain-derived neurotropic factor and behavior in mice” 2011 Gastroenterology 602
8th Collins et al. [63] “The interplay between the intestinal microbiota and the brain” 2012 Nature Reviews Microbiology 566
8th Berer et al. [64] “Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination” 2011 Nature 566
10th De Vadder et al. [65] “Microbiota-generated metabolites promote metabolic benefits via gut-brain neural circuits” 2014 Cell 525
11th Neufeld et al. [66] “Reduced anxiety-like behavior and central neurochemical change in germ-free mice” 2011 Neurogastroenterology and Motility 522
12th O’Mahony et al. [67] “Early Life Stress Alters Behavior, Immunity, and Microbiota in Rats: Implications for Irritable Bowel Syndrome and Psychiatric Illnesses” 2009 Biological Psychiatry 521
13th Clarke et al. [68] “The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner” 2013 Molecular Psychiatry 476
14th Sampson et al. [69] “Gut microbiota regulate motor deficits and neuroinflammation in a model of parkinson’s disease” 2016 Cell 455
15th Tillisch et al. [70] “Consumption of fermented milk product with probiotic modulates brain activity” 2013 Gastroenterology 445
16th Rhee et al. [71] “Principles and clinical implications of the brain-gut-enteric microbiota axis” 2009 Nature Reviews Gastroenterology and Hepatology 444
17th Braniste et al. [72] “The gut microbiota influences blood-brain barrier permeability in mice” 2014 Science Translational Medicine 378
18th Scheperjans et al. [73] “Gut microbiota are related to Parkinson’s disease and clinical phenotype” 2015 Movement Disorders 361
19th O’Mahony et al. [74] “Serotonin, tryptophan metabolism and the brain-gut-microbiome axis” 2015 Behavioural Brain Research 356
20th Cryan and O’Mahony [75] “The microbiome-gut-brain axis: From bowel to behavior” 2011 Neurogastroenterology and Motility 347
  1. SCR Standard competition ranking
  2. aEqual citations have the same ranking number, and then a gap is left in the ranking numbers