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Table 3 Subgroup analysis of IgG-levels

From: Association between serum IgG level and clinical course in primary sclerosing cholangitis

  Study cohort Normal IgG levels (N = 82) Elevated IgG levels (N = 66) p-value
Gender [Male %] 105 (70.9%) 55 (67.1%) 50 (75.8%) 0.32
Median age at initial diagnose [years] 33.5 (26–47) 40 (28–50) 30 (23–39) 0.001 1
Presence of IBD [N, %] 99 (66.9%) 50 (50.5%) 49 (49.5%) 0.12
AIH/PSC overlap [N, %] 5 (3.4%) 2 (2.4%) 3 (4.5%) 0.73
Dominant stenosis 87 (58.7%) 48 (55.2%) 39 (44.8%) 0.52
BMI 22.7 (17.1–31.9) 22.2 (17.1–27.1) 23.4 (19.9–31.9) 0.1
Mayo Risk score −0.521 (−1.15–0.52) −0.273 (−1.07–0.83) −0.107 (− 1.02–1.01) 0.41
MELD 6 (6–15) 6 (6–15) 6 (6–14) 0.4
Presents of CCA [N, %] 12 (8.1%) 7 (8.5%) 5 (7.6%) 0.82
Death [N, %] 37 (25%) 15 (18.3%) 22 (33.3%) 0.04 2
OLT [N, %] 32 (21.6%) 13 (15.9%) 19 (29.8%) 0.172
Re-OLT [N, %] 9 (6.1%) 4 (4.9%) 5 (4.6%) 0.52
Combined endpoint (death and OLT) 57 (38.5%) 23 (40.4%) 34 (59.6%) 0.004 2
  1. Table shows differences between the subgroup of patients with normal (N = 82) and elevated IgG-levels (N = 66). Patients with elevated IgG levels were significant younger than patients with IgG levels within the normal range (p < 0.005). Patients with elevated IgG levels died more often or reached the combined endpoint (death and OLT) compared to patients that had IgG levels within the normal range (p < 0.05 and p < 0.005, respectively. There was a trend towards an increased number of orthotopic liver transplantation (OLT) in patients with hypergammaglobulinemia (p = 0.057). Bold values indicates significant P-values (<0.05)
  2. Abbreviations: IBD = inflammatory bowel disease, AIH/PSC = autoimmune hepatitis/primary sclerosing cholangitis, MELD score = Model for End-stage Liver Disease, CCA = cholangiocarcinoma, OLT = orthotopic liver transplantation
  3. 1Mann-Witney- U test was applied
  4. 2Chi2-Test was applied
  5. 3Fisher’s exact test was applied