Table 1 Demographic and clinical characteristics of the different serum study groups

Age (years)

39.3 ± 6.3

40.3 ± 7.8

47.4 ± 9.2

51.1± 10.5

45.9 ± 9.8

0.066

Gender (male/female)

37/32

58/43

34/28

51/29

82/44

0.342

Alanine aminotransferase (U/L)

24.6 ± 17.2

98.8 ± 67.7

70.8 ± 26.1

63.1 ± 62.3

81.4 ± 59.9

0.008

Aspartate aminotransferase (U/L)

35.8 ± 6.4

101.1 ± 30.2

88.7 ± 19.5

77.6 ± 23.9

111.4 ± 30.1

< 0.001

Total bilirubin (μmol/l)

14.2 ± 3.9

59.7 ± 27.4

16.5 ± 8.8

21.9 ± 10.1

336.2 ± 87.3

< 0.001

Albumin (g/L)

45.6 ± 5.3

40.7 ± 5.7

38.5 ± 7.6

39.0 ± 8.3

32.4 ± 9.9

< 0.001

HBsAg positive (n)

0

101

62

80

126

–

HBV DNA (log₁₀ copies/mL)

0

7.11 ± 3.9

6.37 ± 4.5

6.01 ± 2.9

5.87 ± 2.3

–

Creatinine (μmol/L)

74 ± 44.7

68 ± 30.6

65 ± 19.1

67 ± 52.4

63 ± 40.8

0.007

Prothrombin time (s)

10.8 ± 1.6

12.8 ± 4.0

17.9 ± 8.3

15.4 ± 7.1

25.2 ± 10.5

< 0.001

International normalized ratio

0.98 ± 0.12

1.17 ± 0.2

1.31 ± 0.22

1.25 ± 0.31

2.17 ± 0.47

< 0.001

IL-1β(pg/ml)

5.14 ± 2.64

6.81 ± 4.06

4.37 ± 2.99

5.55 ± 5.39

1.39 ± 0.82

< 0.001

IL-18(pg/m)

9.11 ± 2.66

17.61 ± 19.04

34.21 ± 33.78

50.14 ± 41.02

303.09 ± 274.54

< 0.001