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Table 5 Demographic and clinical characteristics - grouped by baseline perianal disease

From: Current diagnosis and management of Crohn’s disease in China: results from a multicenter prospective disease registry

VariableTotalPatients with perianal diseasePatients without perianal diseaseP value
N (%)499144 (28.9%)355 (71.1%) 
Age (years), mean (SD)32.3 (11.43)28.9 (10.05)33.7 (11.67)< 0.0001
Male, n (%)348 (69.7%)102 (70.8%)246 (69.3%)0.7348
BMI (kg/m2), mean (SD)19.10 (3.198)19.29 (3.254)19.04 (3.182)0.5446
Age at disease onset (years), mean (SD)27.9 (10.63)25.3 (9.40)29.0 (10.92)0.0003
Age group at disease onset (years), n (%)   0.0556
 N499144355 
  ≤ 1629 (5.8%)7 (4.9%)22 (6.2%) 
 17–39401 (80.4%)125 (86.8%)276 (77.7%) 
  ≥ 4069 (13.8%)12 (8.3%)57 (16.1%) 
Age at initial definite diagnosis (years), mean (SD)30.6 (11.01)27.7 (10.02)31.8 (11.19)0.0001
Time from disease onset to initial diagnosis (months), mean (SD)32.0 (46.43)29.0 (38.54)33.2 (49.27)0.3672
Time from initial diagnosis to enrollment (months), mean (SD)20.6 (39.06)14.8 (24.97)22.9 (43.29)0.0345
Time from disease onset to enrollment (months), mean (SD)52.6 (59.08)43.8 (44.55)56.2 (63.75)0.0341
Nicotine use history, n (%)   0.0188
 N442124318 
 Never used382 (86.4%)116 (93.5%)266 (83.6%) 
 Current user36 (8.1%)6 (4.8%)30 (9.4%) 
 Former user24 (5.4%)2 (1.6%)22 (6.9%) 
Alcohol use history, n (%)   0.3203
 N443124319 
 Never used401 (90.5%)116 (93.5%)285 (89.3%) 
 Current user22 (5.0%)3 (2.4%)19 (6.0%) 
 Former user20 (4.5%)5 (4.0%)15 (4.7%) 
Location, n (%)   < 0.0001
 N493143350 
 L1137 (27.8%)23 (16.1%)114 (32.6%) 
 L271 (14.4%)14 (9.8%)57 (16.3%) 
 L3277 (56.2%)105 (73.4%)172 (49.1%) 
 L48 (1.6%)1 (0.7%)7 (2.0%) 
Behavior, n (%)   0.0309
 N495144351 
 B1247 (49.9%)84 (58.3%)163 (46.4%) 
 B2148 (29.9%)32 (22.2%)116 (33.0%) 
 B3100 (20.2%)28 (19.4%)72 (20.5%) 
Crohn’s disease treatment information at baseline, n (%)
 Immunomodulators207 (41.5%)64 (44.4%)143 (40.7%)0.4480
 Anti-TNF agents164 (32.9%)60 (41.7%)104 (29.6%)0.0098
 Aminosalicylates103 (20.6%)23 (16.0%)80 (22.8%)0.0896
 Steroids99 (19.8%)24 (16.7%)75 (21.4%)0.2350
 Enteral nutrition69 (13.8%)24 (16.7%)45 (12.8%)0.2618
 Antibiotics65 (13.0%)30 (20.8%)35 (10.0%)0.0012
 Anti-tuberculosis27 (5.4%)11 (7.6%)16 (4.6%)0.1705
 Other agentsa115 (23.0%)40 (27.8%)75 (21.4%)0.1251
  1. aOther agents including traditional Chinese medicine, et al. B1 non-stricturing non-penetrating, B2 stricturing, B3 penetrating, BMI body mass index, L1 terminal ileum, L2 colon, L3 ileocolon, L4 upper gastrointestinal tract