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Table 5 Clinical studies of first-line Helicobacter pylori eradication in patients allergic to penicillin

From: Cefuroxime, levofloxacin, esomeprazole, and bismuth as first-line therapy for eradicating Helicobacter pylori in patients allergic to penicillin

Publication yearCountryCenterNumberRegimenITT cure ratePP cure rateAdverse reaction rate
2005 [10]Spainsingle12PPI + CLA + MET 7 days58%64%17%
2005 [31]Puerto Ricosingle17PPI + TET + MET 10 days84%84%unavailable
2006 [32]Japansingle5PPI + TET + MET 7–14 days80%100%unavailable
2010 [11]Spainmultiple50PPI + CLA + MET 7 days54%55%10%
2014 [33]Japansingle11PPI + MET+SIT 7–14 days100%100%64%
2015 [9]Spainmultiple112PPI + CLA + MET 7 days57%59%14%
50PPI + TET + MET+BIS 10 days74%75%14%
2017 [12]Japansingle10PPI + CLA + MET 7 days50%56%unavailable
13VPZ + CLA + MET 7 days92%92%unavailable
20PPI + MET+SIT 7 days100%100%unavailable
14VPZ + MET+SIT 7 days93%100%unavailable
  1. BIS Bismuth, CLA Clarithromycin, MET Metronidazole, ITT Intention-to-treat, PP Per-protocol, PPI Proton pump inhibitor, SIT Sitafloxacin, TET Tetracycline, VPZ Vonoprazan