Cefuroxime, levofloxacin, esomeprazole, and bismuth as first-line therapy for eradicating Helicobacter pylori in patients allergic to penicillin

Table 5 Clinical studies of first-line Helicobacter pylori eradication in patients allergic to penicillin

Publication year	Country	Center	Number	Regimen	ITT cure rate	PP cure rate	Adverse reaction rate
2005 [10]	Spain	single	12	PPI + CLA + MET 7 days	58%	64%	17%
2005 [31]	Puerto Rico	single	17	PPI + TET + MET 10 days	84%	84%	unavailable
2006 [32]	Japan	single	5	PPI + TET + MET 7–14 days	80%	100%	unavailable
2010 [11]	Spain	multiple	50	PPI + CLA + MET 7 days	54%	55%	10%
2014 [33]	Japan	single	11	PPI + MET+SIT 7–14 days	100%	100%	64%
2015 [9]	Spain	multiple	112	PPI + CLA + MET 7 days	57%	59%	14%
2015 [9]	Spain	multiple	50	PPI + TET + MET+BIS 10 days	74%	75%	14%
2017 [12]	Japan	single	10	PPI + CLA + MET 7 days	50%	56%	unavailable
			13	VPZ + CLA + MET 7 days	92%	92%	unavailable
			20	PPI + MET+SIT 7 days	100%	100%	unavailable
			14	VPZ + MET+SIT 7 days	93%	100%	unavailable

BIS Bismuth, CLA Clarithromycin, MET Metronidazole, ITT Intention-to-treat, PP Per-protocol, PPI Proton pump inhibitor, SIT Sitafloxacin, TET Tetracycline, VPZ Vonoprazan

ISSN: 1471-230X