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Table 3 Variable analysis of factors affecting eradication efficacy

From: Cefuroxime, levofloxacin, esomeprazole, and bismuth as first-line therapy for eradicating Helicobacter pylori in patients allergic to penicillin

Variable, n/N (%)

Univariable analysis

Multivariable analysis

Eradication efficacy (n = 147)

P value

OR (95% CI)

P value

Age

 < 35 years

40/45 (88.9)

0.991

  

 35–55 years

59/67 (88.1)

  

 > 55 years

31/35 (88.6)

  

Gender:

 female

61/68 (89.7)

0.655

  

 male

69/79 (87.3)

Body mass index:

 < 22.0 kg/m2

38/42 (90.5)

0.856

  

 22.0–25.0 kg/m2

60/68 (88.2)

 > 25.0 kg/m2

32/37 (86.5)

Cigarette smoking:

 yes

19/22 (86.4)

0.742

  

 no

111/125 (88.8)

Alcohol drinking:

 yes

21/25 (84.0)

0.447

  

 no

109/122 (89.3)

Diagnosis:

 PUD

14/14 (100.0)

0.361

  

 NUD

53/61 (86.9)

 UID

63/72 (87.5)

H. pylori density a:

 +

25/29 (86.2)

0.929

  

 ++

 +++

24/27 (88.9)

17/19 (89.4)

Compliance:

 good

128/142 (90.1)

< 0.001

18.000

0.013

 poor

2/5 (40.0)

(1.843–175.775)

 

Cefuroxime resistance b:

 susceptible

56/61 (91.8)

0.002

36.000

 

 resistant

1/3 (33.3)

(2.500–518.371)

0.008

Levofloxacin resistance b:

 susceptible

36/38 (94.7)

0.079

  

 resistant

21/26 (80.8)

  1. CI Confidence interval, NUD Non-ulcer dyspepsia, OR Odds ratio, PUD Peptic ulcer disease, UID Uninvestigated dyspepsia
  2. aData for H. pylori density were available in 75 patients
  3. bData for H. pylori antimicrobial sensitivity were available in 64 patients
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BMC Gastroenterology

ISSN: 1471-230X

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