Table 3 Main characteristics of the studies included in the meta-analysis
Author | Year | Type of study | Region of study | Mean age (years) | Number of population | Number of any relapse | Number of heavy relapse | Follow-up time (months) |
|---|---|---|---|---|---|---|---|---|
Starzl TE [30] | 1988 | Retrospective Cohort | US-Canada | - | 35 | 2 | - | 24 |
Bird GL [12] | 1990 | Retrospective Cohort | Europe | - | 18 | 4 | - | - |
Kumar S [31] | 1990 | Retrospective Cohort | US-Canada | 48.2 | 52 | 6 | 2 | 25 |
Doffoel M [32] | 1992 | Retrospective Cohort | Europe | - | 57 | 19 | - | - |
Knechtle SJ [33] | 1992 | Case-control | US-Canada | 51 | 32 | 4 | - | - |
Lucey MR [34] | 1992 | Retrospective Cohort | US-Canada | 44 | 45 | 5 | 2 | 15 |
Berlakovich GA[35] | 1994 | Retrospective Cohort | Europe | 47.6 | 44 | 14 | 7 | 33 |
Howard L [36] | 1994 | Retrospective Cohort | Europe | 50 | 20 | 19 | 16 | 34 |
Osorio RW [37] | 1994 | Prospective Cohort | US-Canada | 47 | 37 | 7 | 3 | 21 |
Gerhardt TC [38] | 1996 | Retrospective Cohort | US-Canada | 49 | 41 | 20 | 2 | 47 |
Tringali RA [39] | 1996 | Retrospective Cohort | US-Canada | 47.4 | 58 | 12 | 10 | 28 |
Tripp LE [40] | 1996 | Retrospective Cohort | US-Canada | 49 | 68 | 9 | 5 | - |
Zibari GB [41] | 1996 | Retrospective Cohort | US-Canada | 47 | 29 | 2 | - | - |
Anand AC [42] | 1997 | Retrospective Cohort | Europe | 47.5 | 39 | 5 | - | 25 |
Coffman KL [43] | 1997 | Prospective Cohort | US-Canada | - | 91 | 18 | - | - |
Everson G [44] | 1997 | Retrospective Cohort | US-Canada | 53 | 62 | 11 | 6 | 12 |
Foster PF [24] | 1997 | Retrospective Cohort | US-Canada | 48.6 | 63 | 13 | - | 49.3 |
Lucey MR [45] | 1997 | Retrospective Cohort | US-Canada | 46 | 50 | 17 | - | 63 |
Reeck UH [46] | 1997 | Retrospective Cohort | Europe | - | 52 | 6 | - | - |
Shakil AO [47] | 1997 | Retrospective Cohort | US-Canada | 41 | 8 | 3 | - | - |
Stefanini GF [48] | 1997 | Retrospective Cohort | Europe | 47 | 11 | 3 | 1 | 48 |
DiMartini A [49] | 1998 | Retrospective Cohort | US-Canada | 49.5 | 63 | 15 | - | - |
Fabrega E [50] | 1998 | Retrospective Cohort | Europe | 49 | 44 | 8 | - | 37.8 |
Heinemann A [51] | 1998 | Retrospective Cohort | Europe | 45.6 | 13 | 4 | - | - |
Tang H [52] | 1998 | Retrospective Cohort | Europe | 48 | 56 | 28 | 9 | 24 |
Conjeevaram HS [53] | 1999 | Retrospective Cohort | US-Canada | 47 | 68 | 8 | 8 | - |
Gledhill J [54] | 1999 | Retrospective Cohort | Europe | 48 | 31 | 7 | - | 13.5 |
Newton SE [55] | 1999 | Retrospective Cohort | US-Canada | 47 | 122 | 33 | - | 62 |
Pageaux GP [18] | 1999 | Retrospective Cohort | Europe | 48.8 | 47 | 15 | 5 | 42.1 |
Romano DR [56] | 1999 | Case-control | Europe | 47.6 | 152 | 7 | - | - |
Abosh D [57] | 2000 | Retrospective Cohort | US-Canada | 50 | 10 | 5 | 5 | 10 |
Berlakovich GA [58] | 2000 | Retrospective Cohort | Europe | - | 118 | 15 | - | 53.7 |
Burra P [59] | 2000 | Prospective Cohort | Asia Pacific | 48 | 34 | 11 | 4 | 40.1 |
DiMartini A [60] | 2000 | Retrospective Cohort | Europe | 50 | 72 | 4 | 1 | - |
Jain A [61] | 2000 | Retrospective Cohort | US-Canada | 50.8 | 185 | 37 | 1 | 94 |
Pereira SP [62] | 2000 | Retrospective Cohort | Europe | 51 | 56 | 28 | 15 | 30 |
Platz KP [21] | 2000 | Retrospective Cohort | Europe | - | 117 | 30 | - | - |
Bellamy CO [63] | 2001 | Retrospective Cohort | US-Canada | 53 | 123 | 13 | - | 84 |
DiMartini A [64] | 2001 | Prospective Cohort | US-Canada | - | 36 | 8 | - | - |
Gish RG [65] | 2001 | Prospective Cohort | US-Canada | 47 | 61 | 12 | - | 82.8 |
Karman JF [66] | 2001 | Retrospective Cohort | US-Canada | 49 | 19 | 4 | - | 36 |
Mackie J [15] | 2001 | Retrospective Cohort | Europe | 51 | 46 | 21 | 3 | 25 |
Tome S [67] | 2002 | Prospective Cohort | Europe | 51 | 68 | 7 | 2 | 38 |
Berlakovich GA [68] | 2004 | Case-control | Europe | 51.5 | 44 | 3 | - | 43.5 |
Jauhar S [14] | 2004 | Retrospective Cohort | US-Canada | 51 | 11 | 17 | 15 | 44.1 |
Miguet M [69] | 2004 | Prospective Cohort | Europe | 48.7 | 51 | 13 | 9 | 35.7 |
Björnsson E [20] | 2005 | Retrospective Cohort | Europe | 53 | 93 | 32 | 7 | 31 |
Cuadrado A [10] | 2005 | Retrospective Cohort | Europe | 48.9 | 54 | 14 | 14 | 99.2 |
DiMartini A [70] | 2006 | Prospective Cohort | US-Canada | 49.7 | 167 | 70 | 43 | - |
Hwang S [71] | 2006 | Retrospective Cohort | US-Canada | 50 | 15 | 3 | - | 41 |
Kelly M [72] | 2006 | Retrospective Cohort | Asia Pacific | 50.1 | 90 | 28 | 18 | 67 |
De Gottardi A [29] | 2007 | Retrospective Cohort | Europe | 51.3 | 387 | 46 | 46 | 61.2 |
Dumortier J [73] | 2007 | Retrospective Cohort | Europe | 50 | 305 | 37 | 37 | 63 |
Newton SE [74] | 2007 | Cross sectional | US-Canada | - | 18 | 4 | - | - |
Nickels M [75] | 2007 | Retrospective Cohort | US-Canada | 48.8 | 27 | 8 | - | 23.4 |
Pfitzmann R [8] | 2007 | Retrospective Cohort | Europe | 51.2 | 290 | 56 | 23 | 89 |
Vieira A [76] | 2007 | Retrospective Cohort | Other(Brazil) | 47 | 17 | 2 | - | 29.6 |
Wells JT [77] | 2007 | Retrospective Cohort | Europe | 50.3 | 148 | 24 | 20 | 90.5 |
Gedaly R [23] | 2008 | Retrospective Cohort | US-Canada | 52 | 142 | 27 | - | 41.2 |
Immordino G [17] | 2009 | Retrospective Cohort | US-Canada | 53.2 | 110 | 13 | - | - |
Tandon P [26] | 2009 | Retrospective Cohort | US-Canada | 52 | 171 | 41 | 22 | 64.8 |
Biselli M [78] | 2010 | Retrospective Cohort | Europe | 48 | 49 | 13 | 3 | 58 |
Chen GH [79] | 2010 | Retrospective Cohort | Asia Pacific | 52.8 | 16 | 1 | - | 32.4 |
DiMartini A [80] | 2010 | Prospective Cohort | US-Canada | 52 | 208 | 95 | - | - |
Karim Z [81] | 2010 | Retrospective Cohort | US-Canada | 50.5 | 80 | 8 | 8 | - |
Hartl J [82] | 2011 | Retrospective Cohort | Europe | 52.5 | 109 | 17 | - | 31 |
Mathurin P [7] | 2011 | Prospective Cohort | Europe | 47.4 | 26 | 3 | 2 | 20 |
Schmeding M [9] | 2011 | Retrospective Cohort | Europe | 48.9 | 271 | 73 | 73 | - |
Staufer K [83] | 2011 | Prospective Cohort | Europe | 53.5 | 141 | 28 | - | - |
Faure S [84] | 2012 | Retrospective Cohort | Europe | 51 | 206 | 90 | 50 | 81.7 |
Addolorato G [85] | 2013 | Retrospective Cohort | Europe | 49.4 | 92 | 22 | - | - |
Deruytter E [86] | 2013 | Retrospective Cohort | Europe | 56 | 108 | 31 | 17 | 55 |
Kawaguchi Y [87] | 2013 | Retrospective Cohort | Asia Pacific | 52 | 13 | 1 | - | 38 |
Park YH [19] | 2013 | Retrospective Cohort | Asia Pacific | 52 | 18 | 3 | 2 | 57 |
Rice JP [88] | 2013 | Retrospective Cohort | US-Canada | 49.3 | 300 | 48 | 16 | 82 |
Rodrigue JR [107] | 2013 | Retrospective Cohort | US-Canada | 55 | 118 | 40 | 12 | 55 |
Egawa H [16] | 2014 | Retrospective Cohort | Asia Pacific | 35 | 140 | 32 | 21 | 44 |
GrÄ…t M [90] | 2014 | Retrospective Cohort | Europe | 46 | 66 | 22 | - | 88.8 |
Piano S [91] | 2014 | Prospective Cohort | Europe | 60 | 23 | 5 | - | - |
Dumortier J [92] | 2015 | Retrospective Cohort | Europe | 47.2 | 712 | 128 | 128 | 63 |
Hasanin M [93] | 2015 | Cross-sectional | US-Canada | - | 45 | 8 | - | - |
Satapathy SK [94] | 2015 | Retrospective Cohort | US-Canada | 54 | 148 | 16 | 16 | 112.8 |
Zhou M [28] | 2015 | Retrospective Cohort | US-Canada | 54.2 | 35 | 6 | - | - |
Askgaard G [95] | 2016 | Retrospective Cohort | Europe | 54 | 156 | 35 | 35 | - |
Hajifathalian K [96] | 2016 | Prospective Cohort | Europe | 56 | 19 | 4 | - | 40.8 |
Im GY [97] | 2016 | Retrospective Cohort | US-Canada | 41 | 9 | 2 | 1 | 24.5 |
Kollmann D [98] | 2016 | Retrospective Cohort | Europe | - | 382 | 16 | - | 73 |
Lee BP [99] | 2017 | Retrospective Cohort | US-Canada | 51.4 | 31 | 11 | 7 | 19.2 |
Onishi Y [100] | 2017 | Retrospective Cohort | Asia Pacific | 46 | 7 | 1 | - | 60 |
Wigg AJ [101] | 2017 | Retrospective Cohort | Asia Pacific | 50 | 87 | 18 | 14 | 52 |