Skip to main content

Table 1 A Summary of Studies about Excipients Intolerance

From: The culprit of mesalamine intolerance: case series and literature review

Author (Reference) medicine name allergen clinical manifestation of anaphylaxis
Barni et al. [19] benzathine benzylpenicillin soy an itching papular rash
Barbaud et al. [20] pills containing paracetamol and a non-steroidal anti-inflammatory drug carboxymethylcellulose eczematous rashes
pills containingpiroxicam and carboxymethylcellulose carboxymethylcellulose a maculopapular rash in the trunk
pills containing levothyroxine and carboxymethylcellulose carboxymethylcellulose a chronic generalized urticaria
Bigliardi et al. [21] Xyloneural and Kenacort® A 40 carboxymethylcellulose generalized pruritus, urticaria, angioedema in the lips, tachycardia and hypotonia
  carbostesin and Triamcort-Depot® carboxymethylcellulose a generalized urticaria, angioedema in the lips, dizziness and breathing problems
lidocaine and Diprophos® carboxymethylcellulose sweating, flush with generalized pruritus, nausea and angioedema in the feet and in the lips
Bircher et al. [22] lidocaine and Kenacort A10 carboxymethylcellulose nausea, sweating, thoracic oppression, pruritus, generalized urticaria, and hypotension
Caliskaner et al. [23] rifampicin patent blue V (PBV) macular, itchy rashes in the face, ears, buttocks, elbows and knees
Duenas-Laita et al. [24] a generic omeprazole capsule soybean oil hypotension and difficulty breathing
Field et al. [25] triamcinolone acetate carboxymethylcellulose a rash, urticaria and associated periorbital angioedema
Gooch et al. [26] warfarin one of the dyes recurrent, pruritic maculopapular rashes in the trunk and upper limbs
Koppel et al. [27] tegretol FD&C Red 40 rhinorrhea, tearing, and nasal stuffiness
Laing et al. [28] triamcinolone acetonide carboxymethylcellulose lip swelling, wheezing, and an urticarial rash
Millar et al. [29] erythromycin the colouring agent E110 some tingling and swelling in the fingers and feet
Moneret-Vautrin et al. [30] althesin anti-cremophor EL IgG STS antibodies cyanosis, an erythema in the whole trunk
Mumoli et al. [31] furosemide croscarmellose sodium an erythematous cutaneous rash with diffuse itching
Rogkakou et al. [32] ferrous sulphate orange disperse (Sunset Yellow) a severe facial erythema with itching and skin oedema
Rubinger et al. [33] prednisone acacia itching with rash and fever
prednisone tragacanth itching with a rash
prednisone refused to be tested itching with arthralgia
Sims-McCallum et al. [34] 6-Mercaptopurine Tablets cornstarch a red maculopapular rash in the chest, back, and arms with slightly pruritic
van Hooff et al. [35] cyclosporin the solvent headache, erythema in the head, oedema in the conjunctivae, high blood pressure, and tachycardia