Table 2 Characteristics of zinc-induced anemia in WD
From: Anemia following zinc treatment for Wilson’s disease: a case report and literature review
Case source | Age | Zinc dose and course (Bold:high dose) | Chelator drug | HGB (g/dL) | Neutrophils (× 109/L) | Bone marrow | Treatment | Time to normal blood counts |
|---|---|---|---|---|---|---|---|---|
Linn et al[10] | 43 y | 207 mg/d for 30y | No | Anemia | Neutropenia | Unknown | Zinc withdrawal | Unknown |
Horvath et al[11] | 40 y | 200 mg/d for 14y and 250 mg/d for 1y | Initial Penicillamine for 6 m | 7.8 | 0.26 | Ring sideroblasts | Zinc withdrawal | Unknown |
Dzieżyc et al. [12] | 18 y | 72.7 mg/d for 6y | No | 10 | 0.17 | MDS excluded | Zinc withdrawal | 2 months |
Rau et al. [13] | 16 y | High dose for 9 m | Initial Penicillamine for 2y | 5.8 | Neutropenia | MDS, ring sideroblasts | Zinc withdrawal and copper supplement | 8 weeks |
Cortese et al. [14] | 51 y | 242 mg/d for 13y and 484 mg/d for 1y | No | 6.5 | 0.25 | MDS | Zinc dose reduction | Unknown |
Foubert-Samier et al. [15] | 43 y | 142 mg/d for 25y | With Trientine 900 mg/d for 25y | 10.6 | 0.94 | Not performed | Zinc withdrawal | Unknown |
Van den Hamer et al. [16] | 56 y | 484 mg/d for 2y | Initial Penicillamine for 29y | Anemia | Neutropenia | Unknown | Copper supplement | Unknown |
Mohamed et al. [17] | 26y | 80.7 mg/d for 13y | No | 7.4 | 0.2 | vacuolated myeloid and erythroid precursors | Zinc withdrawal and copper supplement | 4 months |
Present case | 11 y 4 m | 240 mg/d for 4y4 m | No | 40 | 0.08 | MDS | Zinc withdrawal | 4 months |