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Table 4 Association between HLA-DQB1*02 gene dosage and clinical and analytical features

From: Influence of HLA on clinical and analytical features of pediatric celiac disease

  Bivariate analysis Multivariate analysis
OR (CI 95%) p OR (CI 95%) p
Clinical presentationa 2.01 (1.04–3.91) 0.04 2.31 (1.01–5.32)* 0.05*
Histological severityb 2.43 (1.13–5.26) 0.02 2.54 (1.16–5.52)** 0.02**
Serologyc 6.64 (0.84–52.7) 0.07 6.09 (0.74–49.87)** 0.09**
Anti-TG2 leveld 0.91 (0.45–1.81) 0.78 0.91 (0.45–1.61)** 0.80**
  1. *corrected by age at onset. When corrected by sex and age: OR (95% CI) = 2.2 (0.95–5.10). p = 0.066;
  2. **corrected by age at onset and sex
  3. ORs are referred to a classical vs. non-classical presentation; b Marsh 3b/Marsh 3c vs. others; c positive vs. negative anti-TG2/EMA, excluding IgA deficient patients; d anti-TG2 ≤ 10 vs. > 10 the upper limit of normality