Fig. 2

Intramucosal cyst and cell infiltration in gastric mucosa of FVB-CA-AhR and wild-type mice. (a) Proper gastric glands in 9 wk. males revealed by HE staining of sections. Arrows denote intramucosal (IM) cysts. (b) The number of IM cysts. For graphs, blue and red asterisks denote significant strain difference with wild-type (WT) mice in males and females at same ages, respectively (Mann-Whitney-U test, P < 0.05). Sharp denotes significant sex-related difference in the same strains at the same age (Mann-Whitney-U test, #P < 0.05). (c) Proper gastric glands in 28 wk. males revealed by HE staining of sections. Asterisks denote extramucosal (EM) cysts. (d) Incidence of EM cysts. Values are expressed as percentage. (e–g) B220⁺ and CD3⁺cells in the proper gastric glands revealed by immunohistochemistry. Arrows denote positive cells; e and f: 6 wk. male, g: 16 wk. male. CA-AhR denotes FVB-CA-AhR. Abbreviations are: LM: lamina muscularis, ML: muscle layer, and LR: limiting ridge. Bars denote 200 μm (a), 500 μm (c), 100 μm (e and f), 500 μm (g, left panel), and 20 μm (g, right panels)