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Fig. 2 | BMC Gastroenterology

Fig. 2

From: Histological improvement in chronic hepatitis B patients treated with bicyclol: real world experience

Fig. 2

Changes in liver histology before and after treatment (× 100). (Male, age = 38 years, the course of treatment = 48 weeks). a. HE staining before treatment: Moderate to massive punctate and patchy necrosis inside the hepatic lobule, moderate lymphocyte infiltration into the portal tracts, and moderate interface inflammation with portal–portal bridging necrosis. b. Warthin–Starry staining before treatment: Fibrosis of the necrotic zones of the portal tracts, fibrotic collapse of the necrotic zones, and moderate formations of spiky fibers and fibrotic septa, leading to hepatic lobular structural deformation; typical nodule not found. Diagnosis: Chronic hepatitis, moderate (G3S3). c. HE staining after treatment: Mild punctate and patchy necrosis inside the hepatic lobule, small amount of lymphocytes in the portal tracts, and no interface inflammation. d. Warthin–Starry staining after treatment: Fibrosis of the portal tracts with sporadic spiky fibers. Diagnosis: Mild lesion (G1S1)

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