Day | −6 | −5 | −4 | −3 | −2 | −1 | 0 | 1 | 2 | 3 | 4 | 5 |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Fludarabine 25 mg/m2/day | ✓ | ✓ | ✓ | ✓ | ✓ | |||||||
Cyclophosphamide 60 mg/kg/day | ✓ | ✓ | ||||||||||
Mesna (dose as per local practice) | ✓ | ✓ | ||||||||||
Standard hydration (as per local practice) | ✓ | ✓ | ||||||||||
Rabbit ATG (Thymoglobulin; Genzyme) (2.5 mg/kg/day) | ✓ | ✓ | ✓ | |||||||||
Methylprednisolone (1 mg/kg/day) | ✓ | ✓ | ✓ | |||||||||
Stem cell reinfusion | ✓ | |||||||||||
G-CSF (filgrastim) (5 μg/kg/day) | ✓ (continued until absolute neutrophil count > 1.0 × 109/L for 2 days) |