Skip to main content

Table 2 Timing of administration of IMP during conditioning phase

From: Autologous stem cell transplantation in refractory Crohn’s disease – low intensity therapy evaluation (ASTIClite): study protocols for a multicentre, randomised controlled trial and observational follow up study

Day

−6

−5

−4

−3

−2

−1

0

1

2

3

4

5

Fludarabine 25 mg/m2/day

       

Cyclophosphamide 60 mg/kg/day

   

       

Mesna (dose as per local practice)

   

       

Standard hydration (as per local practice)

   

       

Rabbit ATG (Thymoglobulin; Genzyme) (2.5 mg/kg/day)

   

      

Methylprednisolone (1 mg/kg/day)

   

      

Stem cell reinfusion

      

     

G-CSF (filgrastim) (5 μg/kg/day)

           

(continued until absolute neutrophil count > 1.0 × 109/L for 2 days)