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Table 2 Timing of administration of IMP during conditioning phase

From: Autologous stem cell transplantation in refractory Crohn’s disease – low intensity therapy evaluation (ASTIClite): study protocols for a multicentre, randomised controlled trial and observational follow up study

Day −6 −5 −4 −3 −2 −1 0 1 2 3 4 5
Fludarabine 25 mg/m2/day        
Cyclophosphamide 60 mg/kg/day            
Mesna (dose as per local practice)            
Standard hydration (as per local practice)            
Rabbit ATG (Thymoglobulin; Genzyme) (2.5 mg/kg/day)           
Methylprednisolone (1 mg/kg/day)           
Stem cell reinfusion             
G-CSF (filgrastim) (5 μg/kg/day)             (continued until absolute neutrophil count > 1.0 × 109/L for 2 days)