Novel 1 L polyethylene glycol-based bowel preparation (NER1006): proof of concept assessment versus standard 2 L polyethylene glycol with ascorbate – a randomized, parallel group, phase 2, colonoscopist-blinded trial

Table 1 Studied Bowel Preparations. Composition and Required Fluid Volumes of the LVPEGs and Control used in this Study^a

Dosing Regimen		LVPEG-1		LVPEG-2		LVPEG-3		LVPEG-4		LVPEG-5		Control
Study Part		1		1		1 and 2		2		2		1 and 2
Dose		Evening	Morning	Evening	Morning	Evening	Morning	Evening	Morning	Evening	Morning	Evening	Morning
Fluid Volume (mL)
	Preparation	750	500	500	750	500	500	500	500	500	500	1000	1000
	Preparation, Total	1250		1250		1000		1000		1000		2000
	Required Additional Fluid	875	875	875	875	1000	1000	500	500	1000	1000	500	500
	Required Additional Fluid, Total	1750		1750		2000		1000		2000		1000
	Required Fluid, Total	3000		3000		3000		2000		3000		3000
Dose Composition (g)
	PEG3350	100	40	40	100	100	40	100	40	100	40	100	100
	Sodium Sulfate	9	-	-	9	9	-	9	-	9	-	7.5	7.5
	Sodium Ascorbate	-	48.1	48.1	-	-	48.1	-	48.1	-	40	5.9	5.9
	Ascorbic Acid	-	7.5	7.5	-	-	7.5	-	7.5	-	-	4.7	4.7

^aOsmotically active ingredients only. All formulations included balanced electrolytes sodium chloride and potassium chloride
Total Required Fluid Volume = Bowel Preparation Reconstituted Volume + Mandatory Additional Clear Fluid Volume

ISSN: 1471-230X