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Table 1 Studied Bowel Preparations. Composition and Required Fluid Volumes of the LVPEGs and Control used in this Studya

From: Novel 1 L polyethylene glycol-based bowel preparation (NER1006): proof of concept assessment versus standard 2 L polyethylene glycol with ascorbate – a randomized, parallel group, phase 2, colonoscopist-blinded trial

Dosing Regimen LVPEG-1 LVPEG-2 LVPEG-3 LVPEG-4 LVPEG-5 Control
Study Part 1 1 1 and 2 2 2 1 and 2
Dose Evening Morning Evening Morning Evening Morning Evening Morning Evening Morning Evening Morning
Fluid Volume (mL)             
  Preparation 750 500 500 750 500 500 500 500 500 500 1000 1000
  Preparation, Total 1250 1250 1000 1000 1000 2000
  Required Additional Fluid 875 875 875 875 1000 1000 500 500 1000 1000 500 500
  Required Additional Fluid, Total 1750 1750 2000 1000 2000 1000
  Required Fluid, Total 3000 3000 3000 2000 3000 3000
Dose Composition (g)             
  PEG3350 100 40 40 100 100 40 100 40 100 40 100 100
  Sodium Sulfate 9 - - 9 9 - 9 - 9 - 7.5 7.5
  Sodium Ascorbate - 48.1 48.1 - - 48.1 - 48.1 - 40 5.9 5.9
  Ascorbic Acid - 7.5 7.5 - - 7.5 - 7.5 - - 4.7 4.7
  1. aOsmotically active ingredients only. All formulations included balanced electrolytes sodium chloride and potassium chloride
  2. Total Required Fluid Volume = Bowel Preparation Reconstituted Volume + Mandatory Additional Clear Fluid Volume