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Table 5 Univariate logistic regressions of health related quality of life variables for abnormal categorical liver function variables

From: The association of liver function and quality of life of patients with liver cancer

Variable Name Child’s classes B to C ALBI grades 2 to 3 Presence of ascites MELD grades 2 to 3
OR 95% CI p-value OR 95% CI p-value OR 95% CI p-value OR 95% CI p-value
EORTC QLQ-C30
 Physical functioning 0.972 0.964–0.981 < 0.001 0.962 0.952–0.973 < 0.001 0.974 0.965–0.982 < 0.001 0.989 0.981–0.997 0.009
 Role functioning 0.982 0.976–0.987 < 0.001 0.975 0.967–0.983 < 0.001 0.982 0.976–0.988 < 0.001 0.992 0.986–0.998 0.007
 Emotional functioning 0.997 0.990–1.005 0.508 0.997 0.989–1.004 0.396 0.995 0.988–1.003 0.262 1.002 0.994–1.010 0.597
 Cognitive functioning 0.988 0.980–0.996 0.002 0.987 0.979–0.996 0.003 0.991 0.980–1.001 0.082 0.993 0.985–1.000 0.064
 Social functioning 0.990 0.984–0.996 0.002 0.986 0.979–0.993 < 0.001 0.989 0.982–0.996 0.001 0.995 0.989–1.001 0.124
 Global quality of life 0.980 0.972–0.987 < 0.001 0.978 0.970–0.986 < 0.001 0.979 0.970–0.987 < 0.001 0.989 0.981–0.996 0.003
 Fatigue 1.022 1.015–1.029 < 0.001 1.025 1.017–1.033 < 0.001 1.025 1.017–1.032 < 0.001 1.010 1.003–1.016 0.003
 Nausea & vomiting 1.014 1.005–1.023 0.002 1.019 1.007–1.031 0.001 1.013 1.004–1.022 0.004 1.009 1.001–1.018 0.037
 Pain 1.005 0.999–1.011 0.099 1.008 1.002–1.015 0.010 1.007 1.000–1.013 0.036 0.998 0.992–1.004 0.479
 Dyspnoea 1.016 1.009–1.022 < 0.001 1.016 1.009–1.023 < 0.001 1.017 1.010–1.024 < 0.001 1.007 1.001–1.013 0.033
 Insomnia 1.009 1.004–1.015 0.001 1.010 1.005–1.016 < 0.001 1.010 1.005–1.016 0.001 0.999 0.993–1.004 0.638
 Appetite loss 1.014 1.008–1.019 < 0.001 1.016 1.010–1.023 < 0.001 1.015 1.009–1.020 < 0.001 1.007 1.002–1.012 0.010
 Constipation 1.004 0.998–1.011 0.205 1.002 0.995–1.010 0.508 1.007 0.999–1.014 0.072 0.998 0.991–1.005 0.586
 Diarrhea 1.017 1.009–1.024 < 0.001 1.016 1.007–1.025 0.003 1.017 1.010–1.025 < 0.001 1.012 1.005–1.019 0.001
 Financial difficulties 1.003 0.998–1.008 0.253 1.007 1.002–1.012 0.011 1.004 0.998–1.009 0.200 1.000 0.995–1.006 0.861
EORTC QLQ-HCC18
 Fatigue 1.024 1.016–1.032 < 0.001 1.030 1.020–1.040 < 0.001 1.022 1.013–1.030 < 0.001 1.008 1.001–1.016 0.027
 Body Image 1.029 1.020–1.038 < 0.001 1.025 1.015–1.035 < 0.001 1.034 1.024–1.044 < 0.001 1.014 1.005–1.022 0.001
 Jaundice 1.024 1.015–1.033 < 0.001 1.011 1.002–1.021 0.020 1.016 1.007–1.025 0.001 1.018 1.009–1.027 < 0.0001
 Nutrition 1.027 1.017–1.037 < 0.001 1.026 1.015–1.037 < 0.001 1.024 1.014–1.033 < 0.001 1.013 1.004–1.022 0.003
 Pain 1.012 1.004–1.020 0.003 1.013 1.004–1.022 0.004 1.013 1.005–1.022 0.001 1.001 0.993–1.009 0.802
 Fever 1.023 1.009–1.037 0.001 1.033 1.014–1.053 0.001 1.012 0.999–1.026 0.079 1.011 0.998–1.025 0.085
 Sex life 1.004 0.999–1.010 0.130 1.007 1.001–1.013 0.017 1.002 0.997–1.008 0.431 1.005 0.999–1.010 0.089
 Abdominal swelling 1.023 1.017–1.029 < 0.001 1.019 1.012–1.026 < 0.001 1.028 1.022–1.035 < 0.001 1.009 1.004–1.015 0.001
Index-scores
 C30 index-score 1.029 1.019–1.040 < 0.001 1.037 1.024–1.049 < 0.001 1.031 1.020–1.042 < 0.001 1.011 1.001–1.021 0.028
 HCC18 index-score 1.045 1.032–1.058 < 0.001 1.044 1.029–1.058 < 0.001 1.043 1.030–1.056 < 0.001 1.020 1.009–1.032 < 0.001
  1. ALBI albumin-bilirubin, CI Confidence intervals, EORTC European Organization for Research and Treatment of Cancer, MELD Model for End-stage Liver Disease, OR Odds ratio