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Table 4 Spearman’s rank correlation analyses between QOL and continuous liver function variables

From: The association of liver function and quality of life of patients with liver cancer

  mean ± SD ln(Albumin) ln(Bilirubin) ln(INR) ln(ALP) ln(ALT) ln(Alb/ALP) ln(ALP/plt)
rho p rho p rho p rho p rho p rho p rho p
EORTC QLQ-C30
 Physical functioning 72.27 ± 23.74 0.404 < 0.001 − 0.235 < 0.001 −0.202 < 0.001 − 0.271 < 0.001 − 0.030 0.514 0.337 < 0.001 − 0.145 0.002
 Role functioning 74.61 ± 32.60 0.318 < 0.001 − 0.262 < 0.001 − 0.194 < 0.001 − 0.304 < 0.001 − 0.187 < 0.001 0.350 < 0.001 − 0.141 0.002
 Emotional functioning 70.67 ± 25.48 − 0.023 0.612 − 0.055 0.232 − 0.018 0.693 − 0.076 0.099 − 0.054 0.239 0.066 0.154 −0.044 0.345
 Cognitive functioning 76.80 ± 24.68 0.133 0.004 −0.115 0.013 −0.146 0.002 −0.072 0.120 −0.029 0.533 0.094 0.041 −0.071 0.121
 Social functioning 68.46 ± 30.33 0.151 0.001 −0.147 0.001 −0.116 0.012 −0.235 < 0.001 − 0.069 0.135 0.241 < 0.001 −0.082 0.076
 Global quality of life 52.22 ± 26.34 0.257 < 0.001 −0.232 < 0.001 −0.167 < 0.001 − 0.230 < 0.001 −0.025 0.595 0.265 < 0.001 −0.070 0.131
 Fatigue 42.93 ± 30.23 −0.321 < 0.001 0.285 < 0.001 0.246 < 0.001 0.316 < 0.001 0.127 0.006 −0.354 < 0.001 0.163 < 0.001
 Nausea & vomiting 11.26 ± 21.41 −0.114 0.013 0.180 < 0.001 0.1406 0.002 0.178 < 0.001 0.093 0.043 −0.183 < 0.001 0.017 0.721
 Pain 32.87 ± 31.97 −0.106 0.022 0.066 0.152 0.084 0.069 0.238 < 0.001 0.050 0.278 −0.229 < 0.001 − 0.003 0.953
 Dyspnoea 29.73 ± 31.46 −0.244 < 0.0001 0.171 < 0.001 0.153 0.001 0.166 < 0.001 0.020 0.661 −0.201 < 0.001 0.111 0.016
 Insomnia 41.88 ± 36.41 −0.165 < 0.001 0.110 0.017 0.104 0.024 0.215 < 0.001 0.111 0.016 −0.228 < 0.001 0.077 0.095
 Appetite loss 32.34 ± 35.88 −0.200 < 0.001 0.245 < 0.001 0.134 0.004 0.300 < 0.001 0.086 0.061 −0.304 < 0.001 0.071 0.121
 Constipation 16.67 ± 27.13 −0.057 0.217 0.006 0.890 −0.007 0.885 −0.019 0.684 0.024 0.598 0.008 0.857 −0.048 0.297
 Diarrhea 16.45 ± 26.87 −0.164 < 0.001 0.222 < 0.001 0.146 0.001 0.126 0.006 0.119 0.009 −0.158 < 0.001 0.143 0.002
 Financial difficulties 51.20 ± 37.22 −0.093 0.044 0.085 0.066 0.086 0.061 0.159 < 0.001 0.062 0.178 −0.163 < 0.001 0.077 0.093
EORTC QLQ-HCC18
 Fatigue 35.23 ± 25.86 −0.305 < 0.001 0.258 < 0.001 0.209 < 0.001 0.295 < 0.001 0.122 0.008 −0.329 < 0.001 0.148 0.001
 Body Image 25.35 ± 22.98 −0.280 < 0.001 0.255 < 0.001 0.152 0.001 0.287 < 0.001 0.064 0.164 −0.320 < 0.001 0.106 0.021
 Jaundice 23.41 ± 22.15 −0.094 0.041 0.226 < 0.001 0.110 0.017 0.096 0.038 0.082 0.074 −0.101 0.027 0.126 0.006
 Nutrition 26.96 ± 21.35 −0.225 < 0.001 0.276 < 0.001 0.149 0.001 0.341 < 0.001 0.134 0.004 −0.343 < 0.001 0.136 0.003
 Pain 23.34 ± 24.57 −0.077 0.096 0.144 0.002 0.094 0.042 0.182 < 0.001 0.057 0.217 −0.178 < 0.001 0.038 0.407
 Fever 6.60 ± 14.39 −0.220 < 0.001 0.117 0.011 0.193 < 0.001 0.097 0.036 0.016 0.735 −0.131 0.004 0.041 0.378
 Sex life 28.74 ± 34.76 −0.053 0.249 0.095 0.040 0.129 0.005 0.170 < 0.001 0.041 0.379 −0.157 < 0.001 0.166 < 0.001
 Abdominal swelling 33.33 ± 35.43 −0.312 < 0.001 0.325 < 0.001 0.225 < 0.001 0.299 < 0.001 0.108 0.019 −0.343 < 0.001 0.175 0.001
Index-scores
 C30 index-score 30.69 ± 19.61 −0.272 < 0.001 0.250 < 0.0001 0.1927 < 0.001 0.301 < 0.0001 0.1245 0.007 −0.329 < 0.001 0.116 0.011
 HCC18 index-score 25.37 ± 17.21 −0.304 < 0.001 0.318 < 0.0001 0.2229 < 0.001 0.343 < 0.0001 0.1188 0.010 −0.371 < 0.001 0.187 < 0.001
  1. ALP alkaline phosphatase, ALT alanine transaminase, EORTC European Organization for Research and Treatment of Cancer, INR international normalized ratio, ln natural logarithm, MELD Model for End-stage Liver Disease, Plt platelet, rho Spearman’s rank correlation coefficient