Table 2 Frequency of reported symptoms/CD-associated medical conditions prior to diagnosis in 2015 and 2006 surveys
|  | Number (%) reporting symptoms/CD-associated medical conditions | Difference in % reporting symptoms/CD-associated medical conditions (2015–2006) | |||||||
|---|---|---|---|---|---|---|---|---|---|
2015a | 2006b | ||||||||
No. | % | (95% CI) | No. | % | (95% CI) | Difference in % | (95% CI) | p-value | |
Abdominal pain/bloating | 1111 | 70.4 | (68.2, 72.7) | 556 | 70.7 | (67.6, 73.9) | −0.3 | (−4.2, 3.6) | 0.867 |
Diarrhoea | 956 | 60.6 | (58.2, 63) | 553 | 70.4 | (67.2, 73.6) | −9.8 | (−13.8, −5.8) | < 0.001 |
Chronic fatigue | 935 | 59.3 | (56.8, 61.7) | 488 | 62.2 | (58.8, 65.6) | −2.9 | (−0.7, 1.3) | 0.173 |
Flatulence | 796 | 50.4 | (48, 52.9) | 368 | 46.9 | (43.4, 50.4) | 3.6 | (−0.07, 7.8) | 0.103 |
Anaemia | 773 | 49.0 | (46.5, 51.5) | 509 | 64.8 | (61.5, 68.2) | −15.9 | (−20, −11.7) | < 0.001 |
Constipation | 464 | 29.4 | (27.2, 31.7) | 207 | 26.3 | (23.2, 29.4) | 3.1 | (−0.7, 6.9) | 0.119 |
Mouth ulcer | 451 | 28.6 | (26.3, 30.8) | 236 | 30.1 | (26.8, 33.3) | −1.5 | (−5.4, 2.4) | 0.455 |
Joint pain | 439 | 27.8 | (25.6,30) | 220 | 28.0 | (24.8, 31.1) | −0.2 | (−4.0, 3.7) | 0.931 |
Headache | 416 | 26.4 | (24.2, 28.5) | 232 | 29.6 | (26.4, 32.8) | −3.2 | (−7.1, 0.7) | 0.101 |
Skin rash | 350 | 22.2 | (20.1, 24.2) | 208 | 26.5 | (23.4, 29.6) | −4.3 | (−8, −0.6) | 0.021 |
Depression | 312 | 19.8 | (17.8, 21.7) | 185 | 23.6 | (20.6, 26.6) | −3.8 | (−7.4, −0.3) | 0.032 |
Other symptomsc | 248 | 15.7 | (13.9, 17.5) | 163 | 20.7 | (17.9, 23.5) | −5.0 | (−8.3, −1.6) | 0.003 |
Osteoporosis | 214 | 13.6 | (11.9, 15.3) | 92 | 11.7 | (9.4, 13.9) | 1.9 | (−1, 4.7) | 0.207 |
Ataxia | 39 | 2.5 | (1.7, 3.2) | 39 | 5.0 | (3.4, 6.5) | −2.5 | (−4.2, −0.8) | 0.001 |
Any symptomc | 1535 | 97.3 | (96.5, 98.1) | 771 | 99.2 | (98.6, 99.8) | −2.0 | (−3, −1) | 0.002 |
1–3 symptoms | 514 | 32.6 | (30.3, 34.9) | 166 | 21.2 | (18.3, 24) | 11.4 | (7.5, 14.9) | < 0.001 |
4+ symptoms | 1021 | 64.7 | (62.3, 67,1) | 605 | 77.8 | (74.1, 80) | −13.1 | (− 16.9, −9.4) | < 0.001 |
No symptoms | 43 | 2.7 | (1.9, 3.5) | 6 | 0.8 | (0.2, 1.4) | 2.0 | (1, 3) | 0.002 |