| |
Number (%) reporting symptoms/CD-associated medical conditions
|
Difference in % reporting symptoms/CD-associated medical conditions (2015–2006)
|
|---|
|
2015a
|
2006b
|
|---|
|
No.
|
%
|
(95% CI)
|
No.
|
%
|
(95% CI)
|
Difference in %
|
(95% CI)
|
p-value
|
|---|
|
Abdominal pain/bloating
|
1111
|
70.4
|
(68.2, 72.7)
|
556
|
70.7
|
(67.6, 73.9)
|
−0.3
|
(−4.2, 3.6)
|
0.867
|
|
Diarrhoea
|
956
|
60.6
|
(58.2, 63)
|
553
|
70.4
|
(67.2, 73.6)
|
−9.8
|
(−13.8, −5.8)
|
< 0.001
|
|
Chronic fatigue
|
935
|
59.3
|
(56.8, 61.7)
|
488
|
62.2
|
(58.8, 65.6)
|
−2.9
|
(−0.7, 1.3)
|
0.173
|
|
Flatulence
|
796
|
50.4
|
(48, 52.9)
|
368
|
46.9
|
(43.4, 50.4)
|
3.6
|
(−0.07, 7.8)
|
0.103
|
|
Anaemia
|
773
|
49.0
|
(46.5, 51.5)
|
509
|
64.8
|
(61.5, 68.2)
|
−15.9
|
(−20, −11.7)
|
< 0.001
|
|
Constipation
|
464
|
29.4
|
(27.2, 31.7)
|
207
|
26.3
|
(23.2, 29.4)
|
3.1
|
(−0.7, 6.9)
|
0.119
|
|
Mouth ulcer
|
451
|
28.6
|
(26.3, 30.8)
|
236
|
30.1
|
(26.8, 33.3)
|
−1.5
|
(−5.4, 2.4)
|
0.455
|
|
Joint pain
|
439
|
27.8
|
(25.6,30)
|
220
|
28.0
|
(24.8, 31.1)
|
−0.2
|
(−4.0, 3.7)
|
0.931
|
|
Headache
|
416
|
26.4
|
(24.2, 28.5)
|
232
|
29.6
|
(26.4, 32.8)
|
−3.2
|
(−7.1, 0.7)
|
0.101
|
|
Skin rash
|
350
|
22.2
|
(20.1, 24.2)
|
208
|
26.5
|
(23.4, 29.6)
|
−4.3
|
(−8, −0.6)
|
0.021
|
|
Depression
|
312
|
19.8
|
(17.8, 21.7)
|
185
|
23.6
|
(20.6, 26.6)
|
−3.8
|
(−7.4, −0.3)
|
0.032
|
|
Other symptomsc
|
248
|
15.7
|
(13.9, 17.5)
|
163
|
20.7
|
(17.9, 23.5)
|
−5.0
|
(−8.3, −1.6)
|
0.003
|
|
Osteoporosis
|
214
|
13.6
|
(11.9, 15.3)
|
92
|
11.7
|
(9.4, 13.9)
|
1.9
|
(−1, 4.7)
|
0.207
|
|
Ataxia
|
39
|
2.5
|
(1.7, 3.2)
|
39
|
5.0
|
(3.4, 6.5)
|
−2.5
|
(−4.2, −0.8)
|
0.001
|
|
Any symptomc
|
1535
|
97.3
|
(96.5, 98.1)
|
771
|
99.2
|
(98.6, 99.8)
|
−2.0
|
(−3, −1)
|
0.002
|
|
1–3 symptoms
|
514
|
32.6
|
(30.3, 34.9)
|
166
|
21.2
|
(18.3, 24)
|
11.4
|
(7.5, 14.9)
|
< 0.001
|
|
4+ symptoms
|
1021
|
64.7
|
(62.3, 67,1)
|
605
|
77.8
|
(74.1, 80)
|
−13.1
|
(− 16.9, −9.4)
|
< 0.001
|
|
No symptoms
|
43
|
2.7
|
(1.9, 3.5)
|
6
|
0.8
|
(0.2, 1.4)
|
2.0
|
(1, 3)
|
0.002
|
- a Sample size: 1578; b Sample size: 788; cIncluding CD-associated medical conditions
