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Table 2 Frequency of reported symptoms/CD-associated medical conditions prior to diagnosis in 2015 and 2006 surveys

From: The impact of diagnosis on health-related quality of life in people with coeliac disease: a UK population-based longitudinal perspective

  Number (%) reporting symptoms/CD-associated medical conditions Difference in % reporting symptoms/CD-associated medical conditions (2015–2006)
2015a 2006b
No. % (95% CI) No. % (95% CI) Difference in % (95% CI) p-value
Abdominal pain/bloating 1111 70.4 (68.2, 72.7) 556 70.7 (67.6, 73.9) −0.3 (−4.2, 3.6) 0.867
Diarrhoea 956 60.6 (58.2, 63) 553 70.4 (67.2, 73.6) −9.8 (−13.8, −5.8) < 0.001
Chronic fatigue 935 59.3 (56.8, 61.7) 488 62.2 (58.8, 65.6) −2.9 (−0.7, 1.3) 0.173
Flatulence 796 50.4 (48, 52.9) 368 46.9 (43.4, 50.4) 3.6 (−0.07, 7.8) 0.103
Anaemia 773 49.0 (46.5, 51.5) 509 64.8 (61.5, 68.2) −15.9 (−20, −11.7) < 0.001
Constipation 464 29.4 (27.2, 31.7) 207 26.3 (23.2, 29.4) 3.1 (−0.7, 6.9) 0.119
Mouth ulcer 451 28.6 (26.3, 30.8) 236 30.1 (26.8, 33.3) −1.5 (−5.4, 2.4) 0.455
Joint pain 439 27.8 (25.6,30) 220 28.0 (24.8, 31.1) −0.2 (−4.0, 3.7) 0.931
Headache 416 26.4 (24.2, 28.5) 232 29.6 (26.4, 32.8) −3.2 (−7.1, 0.7) 0.101
Skin rash 350 22.2 (20.1, 24.2) 208 26.5 (23.4, 29.6) −4.3 (−8, −0.6) 0.021
Depression 312 19.8 (17.8, 21.7) 185 23.6 (20.6, 26.6) −3.8 (−7.4, −0.3) 0.032
Other symptomsc 248 15.7 (13.9, 17.5) 163 20.7 (17.9, 23.5) −5.0 (−8.3, −1.6) 0.003
Osteoporosis 214 13.6 (11.9, 15.3) 92 11.7 (9.4, 13.9) 1.9 (−1, 4.7) 0.207
Ataxia 39 2.5 (1.7, 3.2) 39 5.0 (3.4, 6.5) −2.5 (−4.2, −0.8) 0.001
Any symptomc 1535 97.3 (96.5, 98.1) 771 99.2 (98.6, 99.8) −2.0 (−3, −1) 0.002
1–3 symptoms 514 32.6 (30.3, 34.9) 166 21.2 (18.3, 24) 11.4 (7.5, 14.9) < 0.001
4+ symptoms 1021 64.7 (62.3, 67,1) 605 77.8 (74.1, 80) −13.1 (− 16.9, −9.4) < 0.001
No symptoms 43 2.7 (1.9, 3.5) 6 0.8 (0.2, 1.4) 2.0 (1, 3) 0.002
  1. a Sample size: 1578; b Sample size: 788; cIncluding CD-associated medical conditions