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Table 3 Information about drug-induced hepatotoxicity. The table demonstrates the mean duration of drug administration, the number of cases with hepatotoxicity for each drug and the mean value (range) of liver enzymes during toxicity

From: Hepatobiliary and pancreatic manifestations in inflammatory bowel diseases: a referral center study

Drug

Duration of medication

Overaall number of cases

AST (U/L)

ALT (U/L/)

ALP (U/L)

GGT (U/L)

Cases with ALT > 3

Cases with ALT > 5

Methotrexate

10 weeks (4–20)

9

77 (30–128)

170 (62–382)

100 (43–234)

63 (23–152)

1

 

Azathioprine

5.5 weeks (3–9)

9

383 (69–1165)

280 (113–594)

260 (43–613)

768 (38–2143)

 

3

Mesalamine

15 weeks (13–17)

3

63 (51–75)

97 (71–123)

83 (78–88)

45 (42–48)

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