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Table 3 Information about drug-induced hepatotoxicity. The table demonstrates the mean duration of drug administration, the number of cases with hepatotoxicity for each drug and the mean value (range) of liver enzymes during toxicity

From: Hepatobiliary and pancreatic manifestations in inflammatory bowel diseases: a referral center study

Drug Duration of medication Overaall number of cases AST (U/L) ALT (U/L/) ALP (U/L) GGT (U/L) Cases with ALT > 3 Cases with ALT > 5
Methotrexate 10 weeks (4–20) 9 77 (30–128) 170 (62–382) 100 (43–234) 63 (23–152) 1  
Azathioprine 5.5 weeks (3–9) 9 383 (69–1165) 280 (113–594) 260 (43–613) 768 (38–2143)   3
Mesalamine 15 weeks (13–17) 3 63 (51–75) 97 (71–123) 83 (78–88) 45 (42–48)