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Table 1 Clinical features of patients with small bowel adenocarcinoma in the celiac cohort

From: Small bowel adenocarcinoma as a complication of celiac disease: clinical and diagnostic features

Case #

Sex

HLA

Age at CD diagnosis (yrs)

Age at SBA diagnosis (yrs)

SBA localization

TNM at diagnosis

Presentation

Key diagnostic exam(s) for SBA

Chemotherapy

Survival at 6 years

1

F

DQ2

68

72

Jejunum

T3N0M0

Acute intestinal obstruction

Abdominal X-ray; double contrast upper GI radiography; Exploratory laparotomy

None

Alive

2

F

DQ2 homozygosis

34

69

Jejunum

T2N0M0

Iron deficiency anaemia

VCE; DBE

None

Alive

3

F

DQ2

46

46

Jejunum

T4N2M2

Intestinal sub-occlusion

Small bowel loop ultrasound; CT enteroclysis

FOLFOX + Bevacizumab

Dead after 13 months

4

F

DQ2

38

38

Jejunum

T3N2M0

Intestinal sub-occlusion

CT scan; PET; DBE

FOLFOX

Alive

5

F

DQ2

40

40

Duodenum

T3N2M0

Abdominal pain

OGD

FOLFOX + FOLFIRI

Dead after 63 months

  1. Abbreviations: HLA human leukocyte antigens, CD celiac disease, SBA small bowel adenocarcinoma, F female, TNM tumor, nodes, metastasis classification, OGD oesophago-gastro-duodenal endoscopy, GI gastrointestinal, CT computed tomography, PET positron emission tomography, DBE double balloon enteroscopy, FOLFOX folinic acid (leukovorin), 5-fluorouracil, oxaliplatin, FOLFIRI folinic acid (leukovorin), 5-fluorouracil, irinotecan, VCE video capsule endoscopy