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Table 1 Endpoints

From: Study protocol for a multicenter randomized controlled trial to compare the efficacy of end-ischemic dual hypothermic oxygenated machine perfusion with static cold storage in preventing non-anastomotic biliary strictures after transplantation of liver grafts donated after circulatory death: DHOPE-DCD trial

Primary endpoint

 Symptomatic NAS

Secondary endpoint

 1. Incidence of (a)symptomatic NAS

 2. Severity of NAS

 3. Graft and recipient survival

 4. Primary non-function

 5. Initial poor function

 6. Serum biochemical graft function and injury

 7. Hemodynamic status during reperfusion

 8. ICU and hospital stay

 9. Postoperative complications

 10. Renal function

  DHOPE group only:

 11. Perfusion characteristics

 12. Perfusate biochemical graft function and injury

 13. Perfusate micro ribonucleic acid (miRNA)

 14. Pathobiology of liver and bile duct parenchyma

 15. Metabolic function, including new onset diabetes after transplantation (NODAT)

 16. Costs

 17. Health related quality of life

  1. Abbreviations: DHOPE dual hypothermic oxygenated machine perfusion, ICU intensive care unit, NAS non-anastomotic biliary strictures
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BMC Gastroenterology

ISSN: 1471-230X

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