Plasma levels of TNF-α, IL-6, IFN-γ, IL-12, IL-17, IL-22, and IL-23 in achalasia, eosinophilic esophagitis (EoE), and gastroesophageal reflux disease (GERD)

Table 1 Comparison of biomarker levels among patients with achalasia, EoE, and GERD

Biomarker	Achalasia (n = 53)	EoE (n = 22)	GERD (n = 21)	P-value^a
Biomarker	Median (IQR)	Median (IQR)	Median (IQR)	P-value^a
IL-6	2.45 (2.4)	1.71 (1)	2.05 (3.7)	0.0158 Achalasia vs EoE < 0.05^b
IL-12p70	1.45 (0.9)	2.35 (1.4)	1.19 (0.98)	0.091
IL-17	8.14 (5.6)	9.96 (7.9)	5.89 (6.9)	0.052
IL-22	12.4 (5.7)	10.28 (3.3)	11.35 (4.2)	0.097
IL-23	23.86 (15.0)	26.58 (16.9)	16.45 (12.8)	0.10
TNF-α	4.06 (1.15)	3.97 (2.1)	4.17 (1.3)	0.53
IFN-γ	5.27 (1.7)	5.78 (1.5)	6.12 (1.9)	0.22

ISSN: 1471-230X