Table 5 Genetic variations detected in in the study cohorts
Gene polymorphism | Allele status | Total | Individuals with recurrent episodes of overt jaundice (GS: n = 83) | Individuals with GS and eradicated HCV (n = 18) | Control subjects (n = 100) |
|---|---|---|---|---|---|
UGT1A1*6 | |||||
SNP 211G > A; (n,%) | −/− | 189 | 80 (96.386) | 12 (66.667) | 97 (97) |
*6/− | 10 | 2 (2.409) | 5 (27.778) | 3 (3) | |
*6/*6 | 1 | 0 | 1 (5.555) | 0 | |
UGT1A1*27 | |||||
SNP 686C > A; (n,%) | −/− | 199 | 81 (97.59) | 18 (100) | 100 (100) |
*27/− | 2 | 2(2.409) | 0 | 0 | |
*27/*27 | 0 | 0 | 0 | 0 | |
UGT1A1*28 | |||||
TA repeat A(TA)7TAA; (n,%) | −/− | 100 | 0 | 0 | 100 |
*28/− | 3 | 2 (2.409) | 1(5.555) | 0 | |
*28/*28 | 98 | 81(97.59) | 17 (94.444) | 0 | |
UGT1A1*60 | |||||
SNP -3263 T > A | −/− | 189 | 71 | 13 | 95 |
*60/− | 13 | 5 | 3 | 5 | |
*60/*60 | 9 | 7 | 2 | 0 | |