Table 2 Demographic characteristics and biological phenotypes of carriers of various alles of the GPR65 SNP rs8005161 for patients from the SIBDC
rs8005161 CC | rs8005161 CT or TT | p-value (Fisher or Kruskal-Wallis) | |
|---|---|---|---|
Diagnosis | |||
Crohn’s disease | 1051 (57.1%) | 284 (62.0%) | 0.057 (NS) |
UC / IC | 791 (42.9%) | 174 (38.0%) | |
Gender | 953 (51.7%) | 238 (52.3%) | 0.83 (NS) |
889 (48.3%) | 220 (47.7%) | ||
Age at diagnosis [years] | |||
median, (IQR), | 26.4, (19.1–36.6), | 25.1, (18.2–36.3), | 0.059 (NS) |
min – max | 0.5–81.4 | 2.6–77.5 | |
Disease duration [years] | |||
Median (IQR), | 12.2, (7.3–20.5), | 12.3, (7.3–20.7), | 0.998 (NS) |
min – max | 0.1–52.4 | 0.3–56.6 | |
Last BMI [kg /m2] | |||
median, (IQR), | 23.8, (21.1–26.7), | 23.2, (20.7–26.1), | 0.020 |
min – max | 12.6–47.1 | 13.2–46.3 | |
Intestinal surgery | |||
No (n = 1620) | 1311 (71.2%) | 309 (67.5%) | 0.123 (NS) |
Yes (n = 680) | 531 (28.8%) | 149 (32.5%) | |
Past or current therapy with biologics | |||
No (n = 1107) | 909 (49.3%) | 198 (43.2%) | 0.021 |
Yes (n = 1193) | 933 (50.7%) | 260 (56.8%) | |