Table 1 Genotype frequencies and genotype association analysis of mixed population of IBD patients and healthy subjects
Minor allele homozygous carriers | Minor allele carriers | ||||||||
|---|---|---|---|---|---|---|---|---|---|
rs8005161, GPR65 | |||||||||
CC (%) | CT (%) | TT (%) | p-value | OR (CI) | p-value | OR (CI) | Χ 2 (HWE) p-value | ||
non-IBD | 422 (80.8%) | 95 (18.2%) | 5 (1.0%) | ||||||
IBD | 277 (76.5%) | 78 (21.6%) | 7 (1.9%) | 0.25 | 2.04 (0.64–6.5) | 0.13 | 1.3 (0.93–1.8) | 0.2 | |
UC | 105 (74.5%) | 31 (21.9%) | 5 (3.6%) | 0.04 | 3.8 (1.09–13) | 0.1 | 1.45 (0.93–2.2) | 0.04 | |
CD | 172 (77.8%) | 47 (21.3%) | 2 (0.9%) | 1 | 0.94 (0.18–4.9) | 0.37 | 1.2 (0.82–1.8) | 0.62 | |
rs3742704, GPR65 | |||||||||
AA (%) | AC (%) | CC (%) | p-value | OR (CI) | p-value | OR (CI) | Χ 2 (HWE)p-value | ||
non-IBD | 317 (84.3%) | 57 (15.2%) | 2 (0.5%) | ||||||
IBD | 343 (80.3%) | 78 (18.3%) | 6 (1.4%) | 0.29 | 2.7 (0.53–13) | 0.17 | 1.3 (0.91–1.9) | 0.21 | |
UC | 99 (81.1%) | 23 (18.9%) | 0 | 1 | 0.61 (0.03–13) | 0.4 | 1.3 (0.73–2.1) | 0.46 | |
CD | 239 (80.2%) | 54 (18.1%) | 5 (1.7%) | 0.25 | 3.2 (0.61–17) | 0.18 | 1.3 (0.89–2) | 0.19 | |
rs1805078, GALC | |||||||||
GG (%) | GA (%) | AA (%) | p-value | OR (CI) | p-value | OR (CI) | Χ 2 (HWE) p-value | ||
non-IBD | 270 (88.2%) | 33 (10.8%) | 3 (1%) | ||||||
IBD | 363 (88.1%) | 47 (11.4%) | 2 (0.5%) | 1 | 0.49 (0.082–3) | 1 | 1.01 (0.64–1.6) | 0.71 | |
UC | 116 (86.6%) | 15 (11.2%) | 3 (2.2%) | 0.37 | 2.3 (0.46–11.6) | 0.63 | 1.6 (0.63–2.1) | 0.570 | |
CD | 242 (88.6%) | 31 (11.4%) | 0 | 0.25 | 0.16 (0.008–3.1) | 0.9 | 0.96 (0.58–1.6) | 1 | |