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Table 2 Classification of Papanicolaou Society for assessment of cytological sampling of the pancreatobiliary system. (NET - neuroendocrine tumor; IPMN - intraductal papillary mucinous neoplasm; MCN - mucinous cystic neoplasm)

From: Prospective comparison of slow-pull and standard suction techniques of endoscopic ultrasound-guided fine needle aspiration in the diagnosis of solid pancreatic cancer

Papanicolaou society of cytopathology system for reporting pancreaticobiliary cytology

I. Non-diagnostic


II. Negative (for malignancy)

Benign pancreatic tissue

Acute, chronic or autoimmune pancreatitis

Pseudocyst, lymphoepithelial cyst

Splenule/accessory spleen

III. Atypical


IV. Neoplastic - Benign

Serous cystadenoma

Neuroendocrine microadenoma


IV. Neoplastic - Other

Well-differentiated NET

IPMN, all grades of dysplasia

MCN, all grades of dysplasia

Solid-pseudopapillary neoplasm

V. Suspicious (for malignancy)


VI. Positive or Malignant

Ductal adenocarcinoma of the pancreas and its variants


Acinar cell carcinoma

Poorly differentiated (small and large cell) NET



Metastatic malignancy