Endoscopic and clinicopathological features of intramucosal, histologically mixed-type, low-grade, well-differentiated gastric tubular adenocarcinoma with the potential for late-onset lymph node metastasis

Table 3 Characteristics of the patients in the tub1 and LG-tub1 > tub2 groups

Group (Number of lesions)	Tub1 group (n = 53)	LG-tub1 > tub2 group (n = 7)	P value
Age, mean ± SD years (range)	73.3 ± 7.3 (50–91)	73.7 ± 11.9 (57–93)	0.946
Sex (male/female)	36/17	6/1	0.663
Diameter, mean ± SD mm (range)	11.5 ± 10.7 (2–70)	15.3 ± 7.6 (8–31)	0.368
Macroscopic type
0-IIa/0-IIb/0-IIc^a	36/9/8	1/1/5	0.026^★
Colour on WLE
Whitish/isochromatic/reddish	36/9/8	1/1/5	0.006^★
DL on NBI-ME
Clear/partly unclear	46/7	7/0	0.584
Cytological and glandular architectural atypia grade
Low-grade/high-grade	44/9	1/6	0.001^★
Background mucosal atrophy
C-I, II/C-III, O-I/-II, III^b	0/5/48	0/0/7	1.000
Endoscopic resected metachronous EGC lesion
Yes/No	2/51	3/4	0.009^★
H. pylori status
Positive/negative/eradicated	24/23/6	5/2/0	0.269
Mucin phenotype
Gastric /gastrointestinal/intestinal	6/19/28	4/1/2	0.028^★

Tub1 well-differentiated tubular adenocarcinoma; LG low-grade; Tub2 moderately differentiated tubular adenocarcinoma; LG-tub1 > tub2 LG-tub1 containing tub2; SD standard deviation; WLE white light endoscopy; DL demarcation line; NBI-ME narrow-band imaging with magnifying endoscopy; EGC early gastric cancer; ^a0-IIa superficial elevated; 0-IIb superficial flat; 0-IIc superficial depressed type [3]; ^bKimura-Takemoto classification [24] ^★P < 0.05. Continuous variables were compared using Student’s t-tests. Intergroup differences in the categorical variables were determined using the chi-squared test, Fisher’s exact test, or a likelihood ratio test as appropriate

ISSN: 1471-230X