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Table 1 Baseline characteristics in enrolled acute decompensation of CHB cirrhosis patients in the derivation and external validation cohort

From: Development and external validation of a prognostic nomogram for acute decompensation of chronic hepatitis B cirrhosis

Characteristic Derivation cohort N = 509 External validation cohort N = 620 P value
Age (yr) 51.9 ± 11.8 51.4 ± 11.3 0.540
Male sex 359 (70.5) 463 (74.7) 0.119
Mean arterial pressure (mm Hg) 87.3 ± 10.7 87.3 ± 12.2 0.997
Previous decompensation 197 (38.7) 328 (52.9) <  0.001
Complication
 Hyponatremia 144 (28.3) 249 (40.2) <  0.001
 Ascites 469 (92.1) 496 (80.0) <  0.001
 Bacteria infection 106 (20.8) 75 (12.1) <  0.001
 Gastrointestinal hemorrhage 123 (24.2) 62 (10.0) <  0.001
 Hepatic encephalopathy I-II 100 (19.6) 46 (7.4) <  0.001
 Hepatic encephalopathy III-IV 89 (17.5) 33 (5.3) <  0.001
 Spontaneous bacterial peritonitis 21 (4.1) 19 (3.1) 0.337
 Hepatorenal syndrome 44 (8.6) 61 (9.8) 0.492
Organ failures
 Liver 96 (18.9) 152 (24.5) <  0.001
 Kidney 23 (4.5) 64 (10.3) <  0.001
 Cerebral 89 (17.5) 33 (5.3) <  0.001
 Coagulation 56 (11.0) 120 (19.4) <  0.001
 Respiratory 4 (0.8) 19 (3.1) 0.010
 Circulation 6 (1.2) 9 (1.5) 0.797
Biochemical parameters
 Alanine aminotransferase (U/L) 130.7 ± 388.4 161.0 ± 428.1 <  0.001
 Aspartate aminotransferase (U/L) 125.4 ± 211.3 143.0 ± 322.6 0.005
 γ-Glutamyltransferase (U/L) 60.1 ± 80.9 66.5 ± 86.9 0.015
 Albumin (g/L) 29.5 ± 16.3 29.7 ± 5.8 0.764
 Total bilirubin (mg/dL) 6.8 ± 9.3 9.6 ± 13.7 0.004
 Serum creatinine (μmol/L) 80.3 ± 58.1 89.9 ± 84.8 0.016
 Serum sodium (mmol/L) 137.0 ± 5.4 134.6 ± 6.8 <  0.001
 International normalized ratio 1.7 ± 1.5 2.0 ± 1.3 0.001
 White blood cell count (× 109/L) 5.5 ± 4.0 6.4 ± 4.8 0.009
 Neutrophil count (×109/L) 4.1 ± 5.8
 Platelet (×109/L) 73.2 ± 55.2 79.1 ± 59.2 0.240
 HBV-DNA (log copies/ml) 4.1 ± 1.7 4.4 ± 1.6 <  0.001
Mortality
 7 days 19(3.7) 71(11.5) <  0.001
 14 days 40(7.9) 116(18.7) <  0.001
 28 days 56(11.0) 170(27.4) <  0.001
  1. Data are the mean ± standard deviation for continuous valiables, and n (%), frequency with percentage for categorical variables