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Table 1 Baseline characteristics in enrolled acute decompensation of CHB cirrhosis patients in the derivation and external validation cohort
| Characteristic | Derivation cohort N = 509 | External validation cohort N = 620 | P value |
|---|---|---|---|
| Age (yr) | 51.9 ± 11.8 | 51.4 ± 11.3 | 0.540 |
| Male sex | 359 (70.5) | 463 (74.7) | 0.119 |
| Mean arterial pressure (mm Hg) | 87.3 ± 10.7 | 87.3 ± 12.2 | 0.997 |
| Previous decompensation | 197 (38.7) | 328 (52.9) | < 0.001 |
| Complication | |||
| Hyponatremia | 144 (28.3) | 249 (40.2) | < 0.001 |
| Ascites | 469 (92.1) | 496 (80.0) | < 0.001 |
| Bacteria infection | 106 (20.8) | 75 (12.1) | < 0.001 |
| Gastrointestinal hemorrhage | 123 (24.2) | 62 (10.0) | < 0.001 |
| Hepatic encephalopathy I-II | 100 (19.6) | 46 (7.4) | < 0.001 |
| Hepatic encephalopathy III-IV | 89 (17.5) | 33 (5.3) | < 0.001 |
| Spontaneous bacterial peritonitis | 21 (4.1) | 19 (3.1) | 0.337 |
| Hepatorenal syndrome | 44 (8.6) | 61 (9.8) | 0.492 |
| Organ failures | |||
| Liver | 96 (18.9) | 152 (24.5) | < 0.001 |
| Kidney | 23 (4.5) | 64 (10.3) | < 0.001 |
| Cerebral | 89 (17.5) | 33 (5.3) | < 0.001 |
| Coagulation | 56 (11.0) | 120 (19.4) | < 0.001 |
| Respiratory | 4 (0.8) | 19 (3.1) | 0.010 |
| Circulation | 6 (1.2) | 9 (1.5) | 0.797 |
| Biochemical parameters | |||
| Alanine aminotransferase (U/L) | 130.7 ± 388.4 | 161.0 ± 428.1 | < 0.001 |
| Aspartate aminotransferase (U/L) | 125.4 ± 211.3 | 143.0 ± 322.6 | 0.005 |
| γ-Glutamyltransferase (U/L) | 60.1 ± 80.9 | 66.5 ± 86.9 | 0.015 |
| Albumin (g/L) | 29.5 ± 16.3 | 29.7 ± 5.8 | 0.764 |
| Total bilirubin (mg/dL) | 6.8 ± 9.3 | 9.6 ± 13.7 | 0.004 |
| Serum creatinine (μmol/L) | 80.3 ± 58.1 | 89.9 ± 84.8 | 0.016 |
| Serum sodium (mmol/L) | 137.0 ± 5.4 | 134.6 ± 6.8 | < 0.001 |
| International normalized ratio | 1.7 ± 1.5 | 2.0 ± 1.3 | 0.001 |
| White blood cell count (× 109/L) | 5.5 ± 4.0 | 6.4 ± 4.8 | 0.009 |
| Neutrophil count (×109/L) | 4.1 ± 5.8 | – | – |
| Platelet (×109/L) | 73.2 ± 55.2 | 79.1 ± 59.2 | 0.240 |
| HBV-DNA (log copies/ml) | 4.1 ± 1.7 | 4.4 ± 1.6 | < 0.001 |
| Mortality | |||
| 7 days | 19(3.7) | 71(11.5) | < 0.001 |
| 14 days | 40(7.9) | 116(18.7) | < 0.001 |
| 28 days | 56(11.0) | 170(27.4) | < 0.001 |
