Table 1 Baseline characteristics in enrolled acute decompensation of CHB cirrhosis patients in the derivation and external validation cohort

Age (yr)

51.9 ± 11.8

51.4 ± 11.3

0.540

Male sex

359 (70.5)

463 (74.7)

0.119

Mean arterial pressure (mm Hg)

87.3 ± 10.7

87.3 ± 12.2

0.997

Previous decompensation

197 (38.7)

328 (52.9)

<  0.001

 Hyponatremia

144 (28.3)

249 (40.2)

<  0.001

 Ascites

469 (92.1)

496 (80.0)

<  0.001

 Bacteria infection

106 (20.8)

75 (12.1)

<  0.001

 Gastrointestinal hemorrhage

123 (24.2)

62 (10.0)

<  0.001

 Hepatic encephalopathy I-II

100 (19.6)

46 (7.4)

<  0.001

 Hepatic encephalopathy III-IV

89 (17.5)

33 (5.3)

<  0.001

 Spontaneous bacterial peritonitis

21 (4.1)

19 (3.1)

0.337

 Hepatorenal syndrome

44 (8.6)

61 (9.8)

0.492

 Liver

<  0.001

 Kidney

23 (4.5)

64 (10.3)

<  0.001

 Cerebral

89 (17.5)

33 (5.3)

<  0.001

 Coagulation

56 (11.0)

120 (19.4)

<  0.001

 Respiratory

4 (0.8)

19 (3.1)

0.010

 Circulation

6 (1.2)

9 (1.5)

0.797

 Alanine aminotransferase (U/L)

130.7 ± 388.4

161.0 ± 428.1

<  0.001

 Aspartate aminotransferase (U/L)

125.4 ± 211.3

143.0 ± 322.6

0.005

 γ-Glutamyltransferase (U/L)

60.1 ± 80.9

66.5 ± 86.9

0.015

 Albumin (g/L)

29.5 ± 16.3

29.7 ± 5.8

0.764

 Total bilirubin (mg/dL)

6.8 ± 9.3

9.6 ± 13.7

0.004

 Serum creatinine (μmol/L)

80.3 ± 58.1

89.9 ± 84.8

0.016

 Serum sodium (mmol/L)

137.0 ± 5.4

134.6 ± 6.8

<  0.001

 International normalized ratio

1.7 ± 1.5

2.0 ± 1.3

0.001

 White blood cell count (× 10⁹/L)

5.5 ± 4.0

6.4 ± 4.8

0.009

 Neutrophil count (×10⁹/L)

4.1 ± 5.8

–

–

 Platelet (×10⁹/L)

73.2 ± 55.2

79.1 ± 59.2

0.240

 HBV-DNA (log copies/ml)

4.1 ± 1.7

4.4 ± 1.6

<  0.001

 7 days

19(3.7)

71(11.5)

<  0.001

 14 days

40(7.9)

116(18.7)

<  0.001

 28 days

56(11.0)

170(27.4)

<  0.001