Table 6 Diagnostic performances of combinations of four serum biomarkers for differentiating HCC from liver disease in patients with AFP < 20 ng/mL
Markers | AUC | Sensitivity (Sn) | Specificity (Sp) | Sn + Sp | PPV | NPV |
|---|---|---|---|---|---|---|
ALT+AST | 0.646 (0.591–0.698) | 0.737 (0.66–0.800) | 0.550 (0.470–0628) | 1.287 | 0.632 (0.560–0.699) | 0.667 (0.5794–0.744) |
NLR + ALT | 0.682 (0.628–0.732) | 0.500 (0.423–0.578) | 0.873 (0.809–0.917) | 1.423 | 0.804 (0.714–0.871) | 0.645 (0.558–0.688) |
NLR + AST | 0.666 (0.611–0.716) | 0.821 (0.753–0.873) | 0.503 (0.424–0.583) | 1.324 | 0.634 (0.565–0.697) | 0.728 (0.635–0.805) |
NLR + AST + ALT | 0.666 (0.611–0.716) | 0.821 (0.753–0.873) | 0.503 (0.424–0.583) | 1.324 | 0.634 (0.565–0.697) | 0.728 (0.635–0.805) |