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Table 5 Diagnostic performances of three serum biomarkers for differentiating HCC from liver disease in patients with AFP < 20 ng/mL

From: Diagnostic value of alpha-fetoprotein combined with neutrophil-to-lymphocyte ratio for hepatocellular carcinoma

Marker

Cutoff value

AUC

Sensitivity (Sn)

Specificity (Sp)

Sn + Sp

PPV

NPV

ALT

111

0.507 (0.449–0.564)

0.147 (0.096–0.213)

0.953 (0.906–0.981)

1.1

0.767 (0.577–0.901)

0.516 (0.456–0.577)

AST

27

0.660 (0.603–0.713)

0.981 (0.945–0.996)

0.168 (0.112–0.238)

1.149

0.552 (0.492–0.612)

0.893 (0.718–0.977)

NLR

3.355

0.685 (0.629–0.737)

0.423 (0.344–0.505)

0.926 (0.872–0.963)

1.349

0.857 (0.759–0.926)

0.605 (0.539–0.669)

  1. HCC, hepatocellular carcinoma; ALT, alanine aminotransferase; AST, aspartate aminotransferase; AFP, alpha-fetoprotein; NLR, neutrophil-granulocyte ratio; AUC, area under the receiver operating characteristic curve
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BMC Gastroenterology

ISSN: 1471-230X

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