Table 4 Diagnostic performances of combinations of four serum biomarkers for differentiating HCC from liver disease using AFP = 20 ng/mL as cutoff value
Markers | AUC | Sensitivity (Sn) | Specificity (Sp) | Sn + Sp | PPV | NPV |
|---|---|---|---|---|---|---|
AFP + NLR | 0.762 (0.724–0.795) | 0.772 (0.727–0.812) | 0.739 (0.669–0.798) | 1.511 | 0.861 (0.820–0.894) | 0.608 (0.541–0.671) |
AFP + ALT | 0.697 (0.657–0.734) | 0.694 (0.654–0.731) | 0.807 (0.742–0.858) | 1.501 | 0.874 (0.829–0.909) | 0.516 (0.4458–0.575) |
AFP + AST | 0.749 (0.711–0.783) | 0.889 (0.853–0.917) | 0.470 (0.394–0.540) | 1.359 | 0.777 (0.735–0.813) | 0.667 (0.579–0.744) |
ALT+AST | 0.694 (0.654–0.731) | 0.802 (0.759–0.840) | 0.470 (0.394–0.540) | 1.272 | 0.759 (0.714–0.799) | 0.529 (0.451–0.606) |
NLR + ALT | 0.653 (0.612–0.692) | 0.596 (0.545–0.645) | 0.773 (0.705–0.828) | 1.369 | 0.846 (0.797–0.885) | 0.477 (0.420–0.535) |
NLR + AST | 0.736 (0.697–0.771) | 0.892 (0.856–0.919) | 0.409 (0.339–0.483) | 1.301 | 0.760 (0.717–0.798) | 0.643 (0.551–0.726) |
AFP + AST + ALT | 0.749 (0.711–0.783) | 0.889 (0.853–0.917) | 0.470 (0.394–0.540) | 1.359 | 0.777 (0.735–0.813) | 0.667 (0.579–0.744) |
NLR + AST + ALT | 0.736 (0.697–0.771) | 0.892 (0.856–0.919) | 0.409 (0.339–0.483) | 1.301 | 0.760 (0.717–0.798) | 0.643 (0.551–0.726) |
AFP + NLR + ALT | 0.765 (0.728–0.799) | 0.799 (0.759–0.835) | 0.699 (0.627–0.762) | 1.498 | 0.847 (0.806–0.881) | 0.621 (0.552–0.686) |
AFP + NLR + AST | 0.762 (0.724–0.795) | 0.930 (0.899–0.952) | 0.409 (0.339–0.484) | 1.339 | 0.767 (0.73–0.804) | 0.736 (0.640–0.812) |
AFP + AST + ALT+NLR | 0.762 (0.724–0.795) | 0.930 (0.8998–0.952 | 0.409 (0.339–0.484) | 1.339 | 0.767 (0.73–0.804) | 0.736 (0.640–0.812) |