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Table 2 Diagnostic performances of four serum biomarkers for differentiating HCC from liver disease

From: Diagnostic value of alpha-fetoprotein combined with neutrophil-to-lymphocyte ratio for hepatocellular carcinoma

Marker

Cutoff value

AUC

Sensitivity (Sn)

Specificity (Sp)

Sn + Sp

PPV

NPV

ALT

111

0.504 (0.461–0.547)

0.184 (0.146–0.228)

0.909 (0.857–0.947)

1.093

0.810 (0.709–0.887)

0.347 (0.304–0.392)

AST

27

0.660 (0.618–0.699)

0.802 (0.758–0.842)

0.466 (0.391–0.542)

1.268

0.759 (0.713–0.801)

0.529 (0.447–0.610)

AFP

24.64

0.775 (0.738–0.810)

0.561 (0.509–0.612)

0.881 (0.823–0.925)

1.442

0.908 (0.863–0.942)

0.489 (0.433–0.545)

 

20

0.664 (0.624–0.703)

0.577 (0.525–0.628)

0.852 (0.791–0.901)

1.429

0.891 (0.845–0.928)

0.490 (0.433–0.548)

 

40

0.633 (0.592–0.672)

0.501 (0.449–0.554)

0.903 (0.850–0.943)

1.404

0.916 (0.869–0.950)

0.464 (0.410–0.518)

 

100

0.514 (0.467–0.560)

0.442 (0.390–0.494)

0.938 (0.891–0.968)

1.38

0.937 (0.890–0.968)

0.445 (0.393–0.497)

 

200

0.580 (0.538–0.621)

0.396 (0.345–0.448)

0.960 (0.920–0.984)

1.356

0.954 (0.908–0.981)

0.431 (0.382–0.482)

 

188.4

0.585 (0.544–0.626)

0.409 (0.359–0.461)

0.955 (0.912–0.980)

1.364

0.950 (0.903–0.978)

0.435 (0.385–0.486)

NLR

2.979

0.738 (0.699–0.774)

0.539 (0.487–0.591)

0.858 (0.797–0.906)

1.397

0.888 (0.840–0.926)

0.470 (0.415–0.527)

  1. HCC, hepatocellular carcinoma; ALT, alanine aminotransferase; AST, aspartate aminotransferase; AFP, alpha-fetoprotein; NLR, neutrophil-granulocyte ratio; AUC, area under the receiver operation characteristics curve