Risk factor for steatorrhea in pediatric chronic pancreatitis patients

Hao, Lu; Wang, Teng; He, Lin; Bi, Ya-Wei; Zhang, Di; Zeng, Xiang-Peng; Xin, Lei; Pan, Jun; Wang, Dan; Ji, Jun-Tao; Du, Ting-Ting; Lin, Jin-Huan; Wang, Li-Sheng; Zou, Wen-Bin; Chen, Hui; Xie, Ting; Guo, Hong-Lei; Li, Bai-Rong; Liao, Zhuan; Xu, Zheng-Lei; Li, Zhao-Shen; Hu, Liang-Hao

doi:10.1186/s12876-018-0902-z

BMC Gastroenterology

Table 2 Predictive factors for steatorrhea development in pediatric patients after the diagnosis of CP (256 cases)

From: Risk factor for steatorrhea in pediatric chronic pancreatitis patients

Predictors	n (%)	Univariate Analysis		Multivariate Analysis
Predictors	n (%)	P	HR (95% CI)	P	HR (95% CI)
Gender (male)	124 (48.4%)	0.411	0.353 (0.029–4.233)
Age at the onset of CP, y^a	11.573 ± 4.702	0.104	1.121 (0.977–1.286)	0.135
Age at the diagnosis of CP, y^a	18.141 ± 6.762	0.235	0.880 (0.712–1.087)
Smoking history	14 (5.5%)	0.510	4.355 (0.055–346.356)
Alcohol consumption		0.899
0 g/d	241 (94.1%)	Control
0-20 g/d	5 (2.0%)	0.447	0.036 (0.000–2.373E3)
20-80 g/d	7 (2.7%)	0.716	0.043 (0.000–1.029E6)
> 80 g/d	3 (1.2%)	0.735	0.042 (0.000–3.846E6)
Body mass index^a	19.304 ± 3.338	0.738	0.931 (0.611–1.419)
Etiology		0.579
ICP	220 (85.9%)	Control
ACP	2 (0.8%)	0.710	2.081 (0.043–99.757)
Abnormal anatomy of pancreatic duct	22 (8.6%)	0.690	2.271 (0.040–127.502)
HCP	7 (2.7%)	0.912	1.375 (0.005–401.007)
Post-traumatic CP	3 (1.2%)	1.000	1.008 (0.000–2.361E5)
Hyperlipidemic CP	2 (0.8%)	0.065	208.297 (0.719–6.036E4)
Initial manifestations		0.859
Abdominal pain	249 (97.3%)	0.978	1.392E3 (0.000–9.416E228)
Endocrine dysfunction	5 (2.0%)	0.972	1.175E4 (0.000–8.352E229)
Others	2 (0.8%)
Pancreatic stones^bc	170 (66.4%)	0.582	1.540 (0.331–7.173)
Biliary stricture^b	9 (3.5%)	0.678	0.045 (0.000–1.013E5)
DM^b	8 (3.1%)	0.015	51.140 (2.172–1.203E3)	0.806
Pancreatic pseudocyst^b	26 (10.2%)	0.762	1.389 (0.165–11.705)
Morphology of MPD		0.633
Pancreatic stone alone	82 (32.0%)	0.329	0.082 (0.001–12.473)
MPD stenosis alone	52 (20.3%)	0.350	0.060 (0.000–21.656)
MPD stenosis and stone	113 (44.1%)	0.584	0.229 (0.001–44.967)
Complex pathologic changes	9 (3.5%)	Control
Type of pain^b		0.845
Recurrent acute pancreatitis	93 (36.3%)	0.571	0.218 (0.001–42.016)
Recurrent pain	48 (18.8%)	0.950	1.167 (0.009–147.028)
Recurrent acute pancreatitis and pain	92 (35.9%)	0.854	0.637 (0.005–78.045)
Chronic pain	10 (3.9%)	0.670	0.123 (0.000–1.907E3)
Without pain	13 (5.1%)	Control
Severe acute pancreatitis^b	7 (2.7%)	0.023	13.946 (1.442–134.909)	0.023	13.946 (1.442–134.909)
Pancreatic duct successful drainage^bd	29 (11.3%)	0.904	0.774 (0.012–50.413)
Treatment strategy		0.873
Endotherapy alone	44 (17.2%)	0.876	0.739 (0.017–32.985)
Surgery alone	11 (4.3%)	0.621	0.231 (0.001–76.658)
Both endotherapy and surgery	0	0.904	0.774 (0.012–51.413)
Conservative treatment	201 (78.5%)	Control
DM in first−/second−/third-degree relatives	29 (11.3%)	0.489	0.042 (0.000–327.986)
Pancreatic diseases in first−/second−/third-degree relatives (excluding hereditary CP)	12 (4.7%)	0.572	0.278 (0.003–23.531)

CP chronic pancreatitis, DM diabetes mellitus, ICP idiopathic chronic pancreatitis, ACP alcoholic chronic pancreatitis, HCP hereditary chronic pancreatitis, MPD main pancreatic duct, HR hazard ratio, CI confidence interval
^aMean ± SD
^bBefore or at the diagnosis of CP
^cPancreatic calcifications were also regarded as stones that are located in branch pancreatic duct or ductulus
^dPatients with successful MPD drainage are those whose CP was established after ERCP or pancreatic surgery or those who underwent successful MPD drainage during administration when CP diagnosis was established

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ISSN: 1471-230X

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