Fig. 1

Histological features of atrophic gastritis. a Mild atrophic chronic gastritis, showing focal loss of mucosal glands associated with mild chronic inflammation (EE 10x). Chromogranin A immunohistochemical stain shows linear (one arrow) and micronodular (two arrows) neuroendocrine cells hyperplasia. b Moderate atrophic chronic gastritis, showing moderate loss of mucosal glands associated with moderate chronic inflammation (EE 10x). Chromogranin A immunohistochemical stain shows linear (one arrow) and micronodular (two arrows) neuroendocrine cells hyperplasia. c Severe atrophic chronic gastritis, showing diffuse and severe loss of mucosal glands associated with mild chronic inflammation (EE 10x). Chromogranin A immunohistochemical stain shows linear (one arrow) and micronodular (two arrows) neuroendocrine cells hyperplasia. d Gastric carcinoid, characterized by nodular and solid growth pattern of monomorphous neuroendocrine cells (EE 10x left and 20x right), immunoreactive for Chromogranin A (insert)