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Table 1 Patient characteristics at the time of histological diagnosis of NAFLD

From: Hepatocellular carcinoma is the most common liver-related complication in patients with histopathologically-confirmed NAFLD in Japan

Demographic data
 Numbers of patients 402
 Gender, Male / Female, n 245 / 157
 Age, ya 51 (20–87)
 Body mass index, kg/m2a 26.1 (18.1–42.4)
 Presence of previous and current malignancy
  None / Hepatocellular carcinoma / Other malignancy, n 351 / 26 / 30
 Type 2 diabetes mellitus, Absence / Presence, n 276 / 126
 Hypertension, Absence / Presence, n 230 / 172
 Hyperlipidemia, Absence / Presence, n 274 / 128
Histological findings
 Steatosis, 5–33% / > 33–66% / > 66%, n 152 / 149 / 98
 Lobular inflammation
  No foci / < 2 foci / 2–4 foci / > 4 foci per 200× field, n 28 / 242 / 116 / 13
 Ballooning, None / Few cells / Many cells, n 39 / 252 / 108
 Stage, 0 / 1 / 2 / 3 / 4, n 48 / 165 / 63 / 98 / 28
 NAFLD activity score, ≤2 / 3, 4 / ≥5, n 34 / 181 / 184
 Diagnosis according to FLIP algorithm, NASH / non-NASH, n 349 / 50
Laboratory dataa
 Serum aspartate aminotransferase, IU/l 44 (3–378)
 Serum alanine aminotransferase, IU/l 69 (15–783)
 Gamma-glutamyl transpeptidase, IU/l 72 (11–990)
 Platelet count, ×103/mm3 213 (40–471)
 Fasting plasma glucose, mg/dl 101 (65–287)
 HbA1c, % 5.9 (4.4–12.6)
 Uric acid, mg/dl 5.9 (1.9–11.1)
 Total cholesterol, mg/dl 204 (101–370)
 Triglycerides, mg/dl 140 (31–1088)
 High-density lipoprotein cholesterol, mg/dl 45 (14–85)
 Low-density lipoprotein cholesterol, mg/dl 120 (27–243)
 Serum ferritin, μg/l 227 (< 10–2067)
 High sensitive C-reactive protein, mg/dl 0.095 (0.006–2.240)
 Alpha-fetoprotein, μg/l 4 (1–10,930)
 PIVKA-II, AU/l 18 (1–157,050)
  1. Data are number of patients, except those denoted by a, which represent the median (range) values