Fig. 1

Between 1976 and 2017, liver biopsy was performed at our hospital, for patients with liver dysfunction and/or fatty liver, as confirmed by abdominal ultrasonography. NAFLD was confirmed histopathologically in 402 Japanese consecutive patients. Follow-up was missing in 3 patients, and 399 patients were evaluated in sub-cohorts in which patients who had experienced an event were excluded from that specific analysis. Mortality was evaluated in 351 patients, without previous or current malignancies at the time of NAFLD diagnosis