Skip to main content

Advertisement

Table 2 Determinants of biologic treatment and regression results

From: Biologic treatment of Japanese patients with inflammatory bowel disease

Characteristics Overall, ORs, (95%CI) Crohn’s disease, ORs (95%CI) Ulcer Colitis, ORs (95%CI)
Age (reference ≤40 years)
 41–65 years 0.59 (0.37–0.93) 0.41 (0.17–0.95) 0.86 (0.42–1.74)
  > 65 years 0.24 (0.09–0.65) 0.37 (0.05–2.85) 0.31 (0.08–1.26)
Gender (reference male)
 Female 0.77 (0.46–1.29) 0.30 (0.11–0.79) 1.67 (0.77–3.63)
Marriage status (reference married)
 Single 0.68 (0.41–1.10) 0.87 (0.37–2.04) 1.29 (0.60–2.81)
Highest Education (reference college or less)
 Bachelor’s degree 0.76 (0.49–1.18) 0.51 (0.22–1.19) 1.01 (0.51–2.02)
 Master’s degree and higher 0.26 (0.10–0.71) 0.06 (0.01–0.41) 1.45 (0.41–5.16)
Occupation
 Fulltime 2.74 (0.43–7.13) 0.38 (0.01–1.17) 2.38 (0.25–3.00)
 Part-time 2.16 (0.32–4.70) 0.28 (0.01–1.07) 1.57 (0.14–17.08)
 Self employed 2.39 (0.34–6.52) 0.21 (0.01–7.28) 3.21 (0.28–6.28)
 House wife 3.24 (0.46–2.52) 0.25 (0.01–1.69) 1.95 (0.17–2.24)
 Student 5.20 (0.30–9.37) 0 (Omitted) 0 (Omitted)
 Unemployed/Pensioner 3.50 (0.54–2.65) 0.77 (0.02–5.11) 2.44 (0.22–6.58)
Household incomes (reference less than 2 M JPY)
 2–4 M JPY 1.26 (0.55–2.87) 0.25 (0.06–1.03) 1.49 (0.40–5.59)
 4–6 M JPY 1.56 (0.69–3.56) 1.04 (0.28–3.86) 1.16 (0.29–4.56)
 6–8 M JPY 1.50 (0.62–3.61) 1.98 (0.45–8.83) 0.74 (0.17–3.22)
 8–10 M JPY 1.43 (0.51–4.01) 0.84 (0.17–4.27) 0.57 (0.08–4.09)
  > 10 M JPY 1.24 (0.45–3.41) 1.05 (0.18–6.02) 0.51 (0.09–2.71)
Comorbidity
 Dyslipidemia 0.55 (0.23–1.34) 0.73 (0.13–3.96) 0.36 (0.09–1.56)
 Hypertension 0.85 (0.42–1.72) 0.41 (0.11–1.60) 1.20 (0.44–3.28)
 COPD Asthma 1.70 (0.62–4.61) 3.32 (0.39–8.54) 2.00 (0.53–7.57)
 Diabetes 1.42 (0.60–3.33) 0.97 (0.15–6.34) 2.48 (0.80–7.64)
 Depression 0.64 (0.27–1.49) 0.49 (0.10–2.30) 0.61 (0.16–2.36)
 OA and RA 1.27 (0.29–5.52) 0.41 (0.04–4.45) 2.44 (0.24–24.85)
 Gastrointestinal disease 1.03 (0.41–2.57) 0.69 (0.10–4.55) 1.39 (0.39–4.93)
Surgical history
 Previous surgical history 1.98 (1.24–3.16) 1.15 (0.53–2.47) 0.82 (0.28–2.36)
Current treatment
 Nutritional 3.16 (2.00–5.12) 1.90 (0.87–4.12) 2.42 (1.00–5.89)
 5-ASA 0.89 (0.54–1.49) 1.05 (0.46–2.39) 1.24 (0.46–3.35)
 Steroid 1.04 (0.61–1.78) 2.25 (0.81–6.26) 1.19 (0.56–2.56)
 Immunosuppressant 3.15 (1.94–5.12) 1.44 (0.62–3.28) 4.61 (2.25–9.45)
 Cytapheresis 1.23 (0.33–4.64) 0 (Omitted) 2.00 (0.41–9.68)
Time since diagnosis (reference 0–2 years)
 3–8 years 3.63 (1.69–7.76) 1.48 (0.33–6.54) 4.27 (1.33–3.72)
 9–15 years 3.26 (1.42–7.45) 1.10 (0.22–5.52) 3.99 (1.13–4.13)
  > 15 years 4.16 (1.80–9.56) 0.92 (0.20–4.28) 3.95 (1.04–4.90)
Type of hospitals (reference university hospital)
 General/Specialist hospital 0.62 (0.40–0.96) 1.09 (0.50–2.34) 0.41 (0.19–0.84)
 Clinics 0.47 (0.24–0.89) 0.42 (0.10–1.79) 0.43 (0.17–1.09)
Frequency of visit (Reference less than once in a month)
 Once every month 0.91 (0.45–1.84) 1.56 (0.47–5.22) 0.58 (0.22–1.56)
 Once every 2 months 1.83 (0.88–3.82) 14.36 (3.98–51.83) 0.50 (0.17–1.45)
 Once every 3 months 0.09 (0.03–0.27) 0.26 (0.05–1.21) 0.03 (0.01–0.29)
 Less than every 3 months 0 (Omitted) 0 (Omitted) 0 (Omitted)
  1. COPD chronic obstructive pulmonary disease, OA osteoarthritis, RA rheumatoid arthritis, M JPY million Japanese Yen, OR odds ratio, CI confidence interval
  2. Bold numbers indicate significance at 5% level