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Table 2 Evaluation of the diagnostic accuracy of the evaluated strategies for colorectal cancer detection

From: Symptom or faecal immunochemical test based referral criteria for colorectal cancer detection in symptomatic patients: a diagnostic tests study

 

Sensititvity1

P2

Specificity1

P3

Positive PV1

Negative PV1

Positive LR4

Negative LR4

Diagnostic OR4

2017 NG12 referral criteria (n = 1479)

100%

(97.8–100.0)

 

6.8%

(5.6–8.4)

 

14.5%

(12.8–16.5)

100%

(95.0–100.0)

1.07

(1.06–1.09)

NE

NE

CG27 referral criteria (n = 821)

68.2%

(61.5–74.3)

p < 0.001

50.3%

(47.6–53.0)

p < 0.001

17.8%

(15.3–20.6)

91.0%

(89.0–93.0)

1.4

(1.2–1.5)

0.6

(0.5–0.8)

2.2

(1.6–2.9)

f-Hb ≥ 20 μg Hb/g faeces (n = 607)

91.2%

(86.3–94.4)

p < 0.001

69.6%

(67.1–72.0)

p < 0.001

32.3%

(28.6–36.2)

98.0%

(96.9–98.8)

3.0

(2.7–3.3)

0.1

(0.08–0.2)

23.6

(14.5–38.3)

f-Hb ≥ 10 μg Hb/g faeces (n = 696)

93.5%

(89.1–96.3)

p = 0.001

63.4%

(60.7–66.0)

p < 0.001

28.9%

(25.6–32.4)

98.4

(97.2–99.1)

2.6

(2.4–2.8)

0.1

(0.06–0.2)

24.8

(14.3–43.2)

COLONPREDICT Score ≥ 5.6 (n = 463)

90.1%

(85.1–93.6)

p < 0.001

78.7%

(76.4–80.9)

p < 0.001

40.7%

(36.2–45.3)

98.0%

(96.9–98.7)

4.2

(3.8–4.7)

0.1

(0.08–0.2)

33.8

(21.1–54.0)

COLONPREDICT Score ≥ 3.2 (n = 994)

99.5%

(97.0–100.0)

1

45.8%

(43.1–48.2)

p < 0.001

22.9%

(20.3–25.8)

99.8%

(98.9–100.0)

1.8

(1.7–1.9)

0.01

(0.0–0.07)

179

(25–1280)

FAST Score ≥ 4.50 (n = 583)

89.8%

(84.7–93.3)

p < 0.001

71.3%

(68.8–73.7)

p < 0.001

33.2%

(29.4–37.2)

97.8%

(96.6–98.6)

3.13

(2.84–3.44)

0.14

(0.10–0.21)

21.8

(13.8–34.4)

FAST Score ≥ 2.12 (n = 1383)

100.0%

(97.8–100.0)

p = 1

13.9%

(12.1–15.9)

p < 0.001

15.6%

(13.7–17.6)

100%

(97.5–100.0)

1.16

(1.14–1.19)

NE

NE

  1. 1Values are expressed as percentages and its 95% confidence interval
  2. 2Significance of the sensitivity differences when compared with the NG12 referral criteria in McNemar’s test. Differences with p < 0.05 are considered statistically significant
  3. 3Significance of the specificity differences when compared with the NG12 referral criteria in McNemar’s test. Differences with p < 0.05 are considered statistically significant
  4. 4Values are expressed as absolute numbers and its 95% confidence interval
  5. PV, predictive value; LR, likelihood ratio; OR, odds ratio; f-Hb, faecal haemoglobin; NE, non evaluable