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Table 2 Univariate analysis of risk factors associated with survival in 117 patients with hepatic veno-occlusive disease

From: Risk factors for hepatic veno-occlusive disease caused by Gynura segetum: a retrospective study

Variable Rehabilitation Group
(n = 67)
Death Group
(n = 50)
Statistic P value
Age (years) 63.0 (52.3–69.0) 61.5 (48.3–67.8) t = 0.871 0.385
Male/female (%) 67/33 64/36 χ2 = 0.008 0.565
Clinical manifestations, n (%)
 Ascites 67 (100) 49 (98.0) χ2 = 1.352 0.427
 Abdominal distention 66 (98.5) 49 (98.0) χ2 = 0.044 0.834
 Poor appetite 22 (32.8) 26 (52.0) χ2 = 4.346 0.057
 Nausea, vomiting 7 (10.4) 11 (22.0) χ2 = 2.935 0.120
 Malaise 22 (32.8) 17 (34.0) χ2 = 0.895 0.525
 Lower limb oedema 23 (34.3) 23 (46.0) χ2 = 1.653 0.252
 Hepatomegaly 45 (67.2) 37 (74.0) χ2 = 0.638 0.541
 Splenomegaly 22 (32.8) 18 (36.0) χ2 = 0.127 0.844
 Right upper quadrant pain 14 (20.9) 9 (18.0) χ2 = 0.152 0.815
 Weight gain 11 (16.4) 10 (20.0) χ2 = 0.249 0.634
 Encephalopathy 5 (7.5) 14 (28.0) χ2 = 8.878 0.005
 Variceal bleeding 0 3 (6.0) χ2 = 4.126 0.075
Laboratory tests
 WBC (109/L) 6.1 (5.4–9.3) 6.4 (4.5–8.6) t = 0.171 0.864
 RBC (1012/L) 4.4 (4.0–4.8) 4.4 (3.3–5.1) Z = 0.933 0.349
 PLT (109/L) 115.0 (77.0–148.0) 105 (76–144) Z = 0.676 0.750
 ALT (U/L) 69.0 (25.0–201.0) 38.0 (23.0–86.0) Z = 1.040 0.230
 AST (U/L) 100.0 (44.0–189.0) 72.0 (38.0–158.0) Z = 0.902 0.389
 GGT (U/L) 97.0 (61.5–161.0) 113.1 (49.8–176.6) Z = 0.746 0.635
 ALP (U/L) 111.0 (82.5–148.0) 137.0 (84.8–202.0) Z = 1.002 0.267
 TB (μmol/L) 26.7 (19.7–36.4) 43.75 (37.0–83.0) Z = 2.163 <0.001
 DB (μmol/L) 15.1 (12.8–26.1) 27.9 (21.6–59.4) Z = 1.914 0.001
 ALB (g/L) 30.6 (28.9–34.4) 29.8 (27.1–32.5) t = 2.052 0.044
 PT (s) 14.8 (12.4–16.5) 15.2 (13.1–18.5) t = −0.774 0.442
 BUN (mmol/L) 5.0 (3.8–6.3) 7.0 (3.6–9.51) Z = 1.503 0.022
 CR (μmol/L) 71.0 (58.0–84.0) 71.0 (53.5–94.0) t = − 0.088 0.930
 CA-125 (u/ml) 224.5 (136.6–430.7) 270.1 (181.9–429.5) t = −0.083 0.935
 CA199 11.9 (7.8–25.0) 17.6 (8.3–38.8) Z = 0.672 0.757
Treatment, n (%)
 Non-anticoagulation 9 (13.4) 19 (38.0) χ2 = 9.498 0.009
 Anticoagulation 49 (73.1) 26 (52.0)   
 Anticoagulation + TIPS 9 (13.4) 5 (10.0)