Table 2 Univariate analysis of risk factors associated with survival in 117 patients with hepatic veno-occlusive disease
From: Risk factors for hepatic veno-occlusive disease caused by Gynura segetum: a retrospective study
Variable | Rehabilitation Group (n = 67) | Death Group (n = 50) | Statistic | P value |
|---|---|---|---|---|
Age (years) | 63.0 (52.3–69.0) | 61.5 (48.3–67.8) | t = 0.871 | 0.385 |
Male/female (%) | 67/33 | 64/36 | χ2 = 0.008 | 0.565 |
Clinical manifestations, n (%) | ||||
Ascites | 67 (100) | 49 (98.0) | χ2 = 1.352 | 0.427 |
Abdominal distention | 66 (98.5) | 49 (98.0) | χ2 = 0.044 | 0.834 |
Poor appetite | 22 (32.8) | 26 (52.0) | χ2 = 4.346 | 0.057 |
Nausea, vomiting | 7 (10.4) | 11 (22.0) | χ2 = 2.935 | 0.120 |
Malaise | 22 (32.8) | 17 (34.0) | χ2 = 0.895 | 0.525 |
Lower limb oedema | 23 (34.3) | 23 (46.0) | χ2 = 1.653 | 0.252 |
Hepatomegaly | 45 (67.2) | 37 (74.0) | χ2 = 0.638 | 0.541 |
Splenomegaly | 22 (32.8) | 18 (36.0) | χ2 = 0.127 | 0.844 |
Right upper quadrant pain | 14 (20.9) | 9 (18.0) | χ2 = 0.152 | 0.815 |
Weight gain | 11 (16.4) | 10 (20.0) | χ2 = 0.249 | 0.634 |
Encephalopathy | 5 (7.5) | 14 (28.0) | χ2 = 8.878 | 0.005 |
Variceal bleeding | 0 | 3 (6.0) | χ2 = 4.126 | 0.075 |
Laboratory tests | ||||
WBC (109/L) | 6.1 (5.4–9.3) | 6.4 (4.5–8.6) | t = 0.171 | 0.864 |
RBC (1012/L) | 4.4 (4.0–4.8) | 4.4 (3.3–5.1) | Z = 0.933 | 0.349 |
PLT (109/L) | 115.0 (77.0–148.0) | 105 (76–144) | Z = 0.676 | 0.750 |
ALT (U/L) | 69.0 (25.0–201.0) | 38.0 (23.0–86.0) | Z = 1.040 | 0.230 |
AST (U/L) | 100.0 (44.0–189.0) | 72.0 (38.0–158.0) | Z = 0.902 | 0.389 |
GGT (U/L) | 97.0 (61.5–161.0) | 113.1 (49.8–176.6) | Z = 0.746 | 0.635 |
ALP (U/L) | 111.0 (82.5–148.0) | 137.0 (84.8–202.0) | Z = 1.002 | 0.267 |
TB (μmol/L) | 26.7 (19.7–36.4) | 43.75 (37.0–83.0) | Z = 2.163 | <0.001 |
DB (μmol/L) | 15.1 (12.8–26.1) | 27.9 (21.6–59.4) | Z = 1.914 | 0.001 |
ALB (g/L) | 30.6 (28.9–34.4) | 29.8 (27.1–32.5) | t = 2.052 | 0.044 |
PT (s) | 14.8 (12.4–16.5) | 15.2 (13.1–18.5) | t = −0.774 | 0.442 |
BUN (mmol/L) | 5.0 (3.8–6.3) | 7.0 (3.6–9.51) | Z = 1.503 | 0.022 |
CR (μmol/L) | 71.0 (58.0–84.0) | 71.0 (53.5–94.0) | t = − 0.088 | 0.930 |
CA-125 (u/ml) | 224.5 (136.6–430.7) | 270.1 (181.9–429.5) | t = −0.083 | 0.935 |
CA199 | 11.9 (7.8–25.0) | 17.6 (8.3–38.8) | Z = 0.672 | 0.757 |
Treatment, n (%) | ||||
Non-anticoagulation | 9 (13.4) | 19 (38.0) | χ2 = 9.498 | 0.009 |
Anticoagulation | 49 (73.1) | 26 (52.0) | ||
Anticoagulation + TIPS | 9 (13.4) | 5 (10.0) | ||