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Table 1 Summary of the endoscopic findings from the seven patients diagnosed with nivolumab-induced colitis

From: The characteristics of nivolumab-induced colitis: an evaluation of three cases and a literature review

 

Age/Gender

Tumour Types

Onseta

Symptoms

Endoscopic Findings

Disease Location

Histological Findings

Treatment

Outcome

Kubo et al. [7]

82/M

Non-small-cell lung cancer

6 weeks

Diarrhoea and abdominal pain

Reddish and oedematous mucosa with loss of vascularity and ulcerations

Left side of the colon

Inflammatory infiltrates with crypt abscesses and Meissen’s plexus degeneration

Mesalazine

Improved

Takayama et al. [8]

89/M

Melanoma

20 weeks

Diarrhoea

Oedematous mucosa with increased mucous exudate and loss of vascularity

Entire colon

Inflammatory infiltrates with crypt abscesses

Mesalazine PSLb

Improved

Takenaka et al. [9]

45/F

Adenocarcinoma of lung

4 weeks

Diarrhoea and abdominal pain

Reddish and oedematous mucosa with ulceration

Left side of the colon

Inflammatory infiltrates with crypt abscesses

PSL Infliximab

Improved

Yanai et al. [10]

51/M

Melanoma

9 weeks

Bloody diarrhoea and abdominal pain

Reddish, oedematous mucosa with increased mucous exudate and loss of vascularity

Entire colon

Inflammatory infiltrates with crypt abscesses and prominent apoptosis

PSLb Infliximab

Improved

Case 1

73/M

Non-small-cell lung cancer

15 weeks

Diarrhoea

Granular mucosa with increased mucous exudate and loss of vascularity

Entire colon

Inflammatory infiltrates with crypt abscesses

Mesalazine

Improved

Case 2

78/M

Adenocarcinoma of lung

7 weeks

Diarrhoea and bleeding

Reddish and oedematous mucosa with loss of vascularity and ulcerations

Left side of the colon

Inflammatory infiltrates with crypt abscesses and cryptitis

PSLb

Improved

Case 3

49/M

Adenocarcinoma of lung

3 weeks

Diarrhoea

Reddish, oedematous mucosa with increased mucous exudate and loss of vascularity

Entire colon

Inflammatory infiltrates with epithelial damage

PSLb

Improved

  1. a Onset of abdominal symptoms after initiation of treatment with nivolumab
  2. b PSL, prednisolone