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Fig. 5 | BMC Gastroenterology

Fig. 5

From: Mesenchymal stem cell transplantation improves chronic colitis-associated complications through inhibiting the activity of toll-like receptor-4 in mice

Fig. 5

MSCs suppressed the expressions of TNF-α, IFN-γ, IL-1β and IL-17A mRNA and proteins in the liver tissues of chronic DSS-induced colitis. a MSCs changed the expressions of TNF-α, IFN-γ, IL-1β and IL-17A mRNA in liver tissues of chronic colitis-associated hepatobiliary disorders. Data were expressed as mean ± SD. aP < 0.05 vs. the DSS + vehicle group; bP < 0.05 vs. the control group. b Representative western blots showing TNF-α, IFN-γ, IL-1β and IL-17A proteins expressions. c Expressions of TNF-α, IFN-γ, IL-1β and IL-17A staining in the DSS + vehicle group were higher than that of the control group, while in the DSS + MSCs group, these expressions decreased. d The expressions of the TNF-α, IFN-γ, IL-1β, and IL-17A protein in liver tissues were significantly increased in the DSS + vehicle group compared with that of the control group, while they were decreased in the DSS + MSCs group. e Quantification of cytokines by immunohistochemistry (original magnifications, × 400)

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