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Fig. 3 | BMC Gastroenterology

Fig. 3

From: Taurocholic acid is an active promoting factor, not just a biomarker of progression of liver cirrhosis: evidence from a human metabolomic study and in vitro experiments

Fig. 3

Cell experiment. a Cell proliferation assay indicated that growth rate of LX-2 cells treated with the different concentrations of Na+/taurocholate were increased compared to that of the control group. Moreover, the effect was dose-dependent. *P < 0.05 compared with control. b and c Western blot indicated that expression of Collagen Type I and α-SMA was increased by TCA treatment as compared with the control. Moreover, effect of TCA on the expression of Collagen Type I and α-SMA was also dose-dependent. TCA50 means 50 μM Na+/taurocholate, and TCA100 means 100 μM Na+/taurocholate. *P < 0.05 compared with control. d and e Western blot indicated that the effect of TCA on Collagen Type I and TLR4 expressions in co-culture groups was more significant than that in mono-culture group. TCA50 means 50 μM Na+/taurocholate, and TCA100 means 100 μM Na+/taurocholate. *P < 0.05 compared with mono-culture group

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