Table 1 Characteristics of studies included in the systematic review
| Â | Sample size | Jadad score | |||
|---|---|---|---|---|---|
Author Year | Setting | NSAIDs(n) | Placebo(n) | NSAIDs intervention | |
Abu-Safieh [21] et al. 2014 | Single center | 89 | 93 | 75Â mg diclofenac intramuscular before ERCP | 3 |
Andrade-Dávila [22] et al. 2015 | Single center | 82 | 84 | 100 mg indomethacin rectal immediately after ERCP | 3 |
Bhatia [23] et al. 2011 | Single center | 121 | 126 | 20Â mg valdecoxib intravenous at the start of ERCP. | 3 |
Cheon [38] et al. 2007 | Single center | 105 | 102 | 50 mg diclofenac 30–90 min oral before ERCP and 4–6 h after | 5 |
Döbrönte [24] et al. 2012 | Single center | 130 | 98 | 100 mg indomethacin rectal 10 min before ERCP | 2 |
Döbrönte [17] et al. 2014 | Multicenter | 347 | 318 | 100 mg indomethacin rectal 10–15 min before sedo-analgesic premedication | 2 |
Elmunzer [25] et al. 2012 | Single center | 295 | 307 | 100Â mg indomethacin rectal immediately after ERCP | 5 |
Hosseini [26] et al. 2016 | Single center | 100 | 105 | 100Â mg of indomethacin rectal two hours before the ERCP procedure | 3 |
Kato [36] et al. 2017 | Single center | 85 | 85 | 400Â mg celecoxib oral 1Â h before ERCP | 2 |
Khoshbaten [27] et al. 2008 | Single center | 50 | 50 | 100Â mg diclofenac rectal after ERCP within 1Â h | 4 |
LevenickV [15] et al. 2015 | Single center | 223 | 226 | 2 * 50Â mg indomethacin rectal during ERCP | 5 |
Lua [16] et al. 2015 | Single center | 69 | 75 | 100Â mg diclofenac rectal immediately after ERCP | 2 |
Mansour-GhanaeiV [35] et al. 2016 | Multicenter | 162 | 162 | 500Â mg naproxen rectal immediately before ERCP. | 3 |
Montaño LozaV [28] et al. 2007 | Single center | 75 | 75 | 100 mg indomethacin rectal two hours before the procedure | 1 |
Murray [29] et al. 2003 | Single center | 110 | 110 | 100Â mg indomethacin rectal 2Â h before ERCP | 5 |
Otsuka [30] et al. 2012 | Multicenter | 51 | 53 | 50 mg (25 mg, if body weight < 50 kg) diclofenac rectal 30 min before ERCP | 2 |
Park [32] et al. 2015 | Single center | 173 | 170 | 90Â mg diclofenac intramuscular immediately after ERCP | 5 |
Patai [31] et al. 2015 | Single center | 270 | 269 | 100Â mg indomethacin rectal within 1Â h before ERCP | 5 |
Quadros Ono’frio [37] et al. 2017 | Single center | 224 | 223 | 100 mg ketoprofen intravenous during 20 min, immediately before the procedure, | 2 |
Sotoudehmanesh [33] et al. 2007 | Single center | 221 | 221 | 100Â mg indomethacin rectal mmediately before ERCP | 4 |
UÇAR [34] et al. (1) 2016 | Single center | 50 | 50 | 100 mg diclofenac sodium rectal 30–90 min before the procedure. | 2 |
UÇAR [34] et al. (2) 2016 | Single center | 50 | 50 | 75 mg diclofenac sodium IM 30–90 min before the procedure. | 2 |