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Table 5 GVHD with villous atrophy in the terminal ileum and treatment response

From: Villous atrophy in the terminal ileum is a specific endoscopic finding correlated with histological evidence and poor prognosis in acute graft-versus-host disease after allo-hematopoietic stem cell transplantation

  Group S Group M Group N P-value P-value
(n = 6) (n = 8) (n = 6) (for trend) Group S versus M + N Group S + M versus N
Mean age (range), years 30 (10–61) 52 (38–58) 57 (33–66) 0.07a 0.08a 0.15a
Sex male/female 3/3 5/3 3/3 > 0.99d 1.54e 1.54e
Days from transplantation, median (range), days 49 (27–231) 69.5 (25–1263) 156.5 (49–1162) 0.47a 0.45a 0.91a
Frequency of diarrhea (times per day), median (range) 14.5 (6–30) 7.5 (0–12) 5.0 (0–8) 0.03a 0.02a 0.23a
GVHD clinical grade
Stages 1/ 2/ 3/ 4
0/ 1/ 2/ 3 2/ 0/ 2/ 4 2/ 2/ 1/ 1 0.09b 0.75c 0.09c
Refractory GVHD 5 3 1 0.02d 0.10e 0.10e
Mortality (per person-year) 0.44 0.53 1.05 0.69f 0.76f 0.80f
  1. Group S, GVHD with severe atrophy of villi in the terminal ileum; group M, GVHD with mild atrophy; group N, absence of atrophy of villi; NS, not significant. a, Student’s t test; b, Jonckheere-Terpstra test; c, Mann-Whitney U test; d, Cochran-Armitage test; e, χ2 test; f, log-rank test