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Table 1 The Freiburg Criteria for macroscopic diagnosis of intestinal acute intestinal GVHD

From: Villous atrophy in the terminal ileum is a specific endoscopic finding correlated with histological evidence and poor prognosis in acute graft-versus-host disease after allo-hematopoietic stem cell transplantation

Grade 1

No clear-cut criteria. It suffers to state that there is no GVHD grdade> 2

Grade 2

Spotted erythema, initial aphthous lesions

Grade 3

Aphthous lesions (Crohn-like) or focal erosions

Grade 4

Confluent defects, ulcerations, complete denudation of the mucosa

  1. GVHD graft-versus-host disease
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BMC Gastroenterology

ISSN: 1471-230X

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