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Table 1 The Freiburg Criteria for macroscopic diagnosis of intestinal acute intestinal GVHD

From: Villous atrophy in the terminal ileum is a specific endoscopic finding correlated with histological evidence and poor prognosis in acute graft-versus-host disease after allo-hematopoietic stem cell transplantation

Grade 1 No clear-cut criteria. It suffers to state that there is no GVHD grdade> 2
Grade 2 Spotted erythema, initial aphthous lesions
Grade 3 Aphthous lesions (Crohn-like) or focal erosions
Grade 4 Confluent defects, ulcerations, complete denudation of the mucosa
  1. GVHD graft-versus-host disease