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Table 4 Stopping boundaries for early termination at interim analysis

From: Additional hepatic 166Ho-radioembolization in patients with neuroendocrine tumours treated with 177Lu-DOTATATE; a single center, interventional, non-randomized, non-comparative, open label, phase II study (HEPAR PLUS trial)

Analysis Sample Size Lower boundary Upper boundary
1 30 5 11
2 36 6 13
3 42 7 14
4 48 15 16