Table 1 Liver involvement as a poor prognostic factor in different therapeutic studies
Author | Treatment | N | Liver involvement | Median survival (months) | 5-year survival | p values |
|---|---|---|---|---|---|---|
Chamberlain (2000) [46] | Surgical resection | 85 | 0–25% | – | 90% | |
25–50% | – | 83% | ||||
50–75% | 47 | 80% | ||||
> 75% | 24 | – | ||||
Yao (2001) [47] | Surgical resection | 16 | ≤4 liver metastases | 46 | – | < 0.05 |
> 4 liver metastases | 20 | – | ||||
Gupta (2005) [48] | TAE or TACE | 123 | 0–25% | 86 | – | |
25–50% | 30 | – | < 0.10 | |||
50–75% | 39 | – | < 0.17 | |||
> 75% | 20 | – | < 0.05 | |||
Kwekkeboom (2008) [14] | PRRT | 310 | None | > 48 | – | |
Moderate | > 48 | – | ||||
Extensive | 25 | – | < 0.01 |