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Table 3 Clinical, laboratory and liver biopsy findings in patients with NAFLD with and without dysmetabolic iron overload syndrome (DIOS), and normal vs. elevated serum ferritin, respectively

From: Hepcidin levels correlate to liver iron content, but not steatohepatitis, in non-alcoholic fatty liver disease

  NAFLD without DIOS (n = 22) NAFLD with DIOS
(n = 16)
With serum ferritin < 350 μg/L (n = 15) With serum ferritin > 350 μg/L (n = 7)
Serum hepcidin (μg/L) 24 ± 19 37 ± 13 53 ± 28*
Serum ferritin (μg/L) 156 ± 78* 621 ± 170 816 ± 285
Transferrin saturation (%) 28 ± 8 25 ± 10 39 ± 9#
Liver iron score 0.03 ± 0.13 0.14 ± 0.24 2.13 ± 0.92*
CRP (mg/L) 2.7 ± 2.2 3.7 ± 4.2 1.8 ± 0.91
Plasma-triglycerides (mmol/L) 2.89 ± 1.09 1.83 ± 1.09 1.95 ± 0.90
Plasma cholesterol (mmol/L) 5.18 ± 0.96 5.25 ± 0.84 5.25 ± 0.71
TNF-α (ng/L) 6.27 ± 5.13 137 ± 316 8.37 ± 5.82
IL-6 (ng/L) 2.47 ± 1.71 32.3 ± 62.7 2.36 ± 1.02
NAS 4.5 ± 1.8 3.6 ± 1.7 4.4 ± 1.8
Steatosis (grade) 2.07 ± 0.80 2.00 ± 1.00 2.72 ± 0.65
Ballooning 1.07 ± 0.59 0.80 ± 0.84 0.63 ± 0.67
Lobular inflammation 1.20 ± 0.86 1.00 ± 0.71 1.00 ± 1.00
Portal inflammation 0.27 ± 0.46 0.60 ± 0.55 0.18 ± 0.40
Fibrosis 1.33 ± 0.90 2.00 ± 1.00 2.72 ± 0.65
  1. Values denote mean ± S.D
  2. *=p < 0.05 (vs. the other groups)
  3. # = p < 0.05 (vs. NAFLD with serum ferritin > 350 μg/L)