Table 2 Time table
Time period | Therapy |
|---|---|
12.2015 | Pat. presented with liver and brain metastases. |
12.2015–03.2016 | Gemcitabine mono 1000 mg/qm d1–8 15 and selective internal radiotherapy (SIRT) analogous to the SIRCCA study protocol.Excision of the tumor in the ileum and one brain metastasis (02.2016) |
05.2016–09.2016 | Capecitabine 500 mg (2–0-2, 5d/week) |
12.09.16 | 1. Cycle: Olaparib (200 mg capsules twice daily, administered orally on days 1–10 of each 21-day cycle) plus paclitaxel (175 mg/m2, administered intravenously on day 1) and carboplatin (4 mg/mL per min) |
04.10.2016 | 2. Cycle: Olaparib (200 mg capsules twice daily, administered orally on days 1–10 of each 21-day cycle) plus paclitaxel (175 mg/m2, administered intravenously on day 1) and carboplatin (4 mg/mL per min) |
31.10.2016 | 3. Cycle: Olaparib (100 mg capsules twice daily (reduced dosage), administered orally on days 1–10 of each 21-day cycle) plus paclitaxel (175 mg/m2, administered intravenously on day 1) and carboplatin (4 mg/mL per min) |
05.12.2016 | 4. Cycle: Olaparib (100 mg capsules twice daily (reduced dosage), administered orally on days 1–10 of each 21-day cycle) plus paclitaxel (175 mg/m2, administered intravenously on day 1) and carboplatin (4 mg/mL per min) |
09.01.2017 | 5. Cycle: Olaparib (100 mg capsules twice daily (reduced dosage), administered orally on days 1–10 of each 21-day cycle) plus paclitaxel (175 mg/m2, administered intravenously on day 1) and carboplatin (4 mg/mL per min) |
02.2017 | liver metastases could be removed |
12.2017 | Last CT-scan staging: still no further tumor manifestations/still no metastasis |